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Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women.

Ganz M, de Bruijne M, Dam EB, Pettersen P, Karsdal MA, Christiansen C, Nielsen M - Int J Biomed Imaging (2012)

Bottom Line: Methods.Results.Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Computer Science, University of Copenhagen, 2100 Copenhagen, Denmark.

ABSTRACT
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated area percentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

No MeSH data available.


Related in: MedlinePlus

A schematic view of AC24. The AC24 is constructed by projecting the AAC to the corresponding aorta wall.
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fig2: A schematic view of AC24. The AC24 is constructed by projecting the AAC to the corresponding aorta wall.

Mentions: The AC24 [15] was constructed by projecting the AACs to the corresponding aorta wall. Then, the aortic sections adjacent to each vertebra L1-L4 were graded by the degree of lesion occupation: 0 for no AAC, 1 for AACs occupying less than 1/3 of the wall they were projected onto, 2 for AACs occupying more than 1/3, but less than 2/3 in the projection, and 3 for a 2/3 or more occupation of the wall. An example of an AC24 scoring can be seen in Figure 2. In addition to the AC24 scores provided by the radiologists, the outlines of the calcifications were used in an alternative computer-based computation of the AC24.


Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women.

Ganz M, de Bruijne M, Dam EB, Pettersen P, Karsdal MA, Christiansen C, Nielsen M - Int J Biomed Imaging (2012)

A schematic view of AC24. The AC24 is constructed by projecting the AAC to the corresponding aorta wall.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3375152&req=5

fig2: A schematic view of AC24. The AC24 is constructed by projecting the AAC to the corresponding aorta wall.
Mentions: The AC24 [15] was constructed by projecting the AACs to the corresponding aorta wall. Then, the aortic sections adjacent to each vertebra L1-L4 were graded by the degree of lesion occupation: 0 for no AAC, 1 for AACs occupying less than 1/3 of the wall they were projected onto, 2 for AACs occupying more than 1/3, but less than 2/3 in the projection, and 3 for a 2/3 or more occupation of the wall. An example of an AC24 scoring can be seen in Figure 2. In addition to the AC24 scores provided by the radiologists, the outlines of the calcifications were used in an alternative computer-based computation of the AC24.

Bottom Line: Methods.Results.Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Computer Science, University of Copenhagen, 2100 Copenhagen, Denmark.

ABSTRACT
Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascular mortality. We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognostic markers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausal women, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of their area, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictive ability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below 25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated area percentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjusting for traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number of calcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified from radiographs may be a useful tool for screening and monitoring risk of CVD mortality.

No MeSH data available.


Related in: MedlinePlus