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Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.

Sawada Y, Nishio Y, Suzuki K, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Itoyama Y, Takahashi S, Fukuda H, Mori E - PLoS ONE (2012)

Bottom Line: Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory.Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field.Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminergic, posterior cortical pathologies may also contribute to this deficit. Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory. In this study, we attempted to identify the neural correlates of the attentional set-shifting deficit in PD using a compound letter task and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography during rest. Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field. Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.

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Related in: MedlinePlus

The results of the ROI-based stepwise multiple regression analyses.7 ROIs are shown in different colors: right DLPFC  =  red, left DLPFC  =  cyan, left VLPFC  =  yellow, right TPO  =  purple, left TPO  =  green, medial parietal cortex  =  white, and left posterior IT  =  blue. The scatterplots illustrate the relationship between the psychophysical task performance scores and the FDG-uptake values in the ROIs. DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; TPO, temporo-parieto-occipital junction; posterior IT, posterior inferior temporal cortex; FDG, 18F-fluorodeoxyglucose.
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pone-0038498-g004: The results of the ROI-based stepwise multiple regression analyses.7 ROIs are shown in different colors: right DLPFC  =  red, left DLPFC  =  cyan, left VLPFC  =  yellow, right TPO  =  purple, left TPO  =  green, medial parietal cortex  =  white, and left posterior IT  =  blue. The scatterplots illustrate the relationship between the psychophysical task performance scores and the FDG-uptake values in the ROIs. DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; TPO, temporo-parieto-occipital junction; posterior IT, posterior inferior temporal cortex; FDG, 18F-fluorodeoxyglucose.

Mentions: Subsequent stepwise multiple regression analyses were conducted using 7 ROIs; namely, the right and left dorsolateral prefrontal cortices (DLPFCs), the left ventrolateral prefrontal cortex (VLPFC), the left posterior inferior temporal cortex (posterior IT), the right and left TPOs, and the left medial parietal cortex. Reductions in CMRglc in the left VLPFC and left posterior IT were predictive of longer RTs on the Global task, whereas reductions in CMRglc in the right DLPFC and right TPO predicted longer RTs on the Local task. Hypometabolism in the right DLPFC and left posterior IT regions predicted longer RTs when performing the Mixed task. The shift cost was best predicted by hypometabolism in the right DLPFC (Table 3 and Figure 4). When the NPI depression score was added to the regression model, reduced CMRglc values in the right DLPFC and the left posterior IT cortex predicted a larger shift cost (Supplementary Table S1). The results of the regression analysis in which the NPI depression score was added to the model were otherwise the same as those of the analyses in which the NPI depression score was not included in the model.


Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.

Sawada Y, Nishio Y, Suzuki K, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Itoyama Y, Takahashi S, Fukuda H, Mori E - PLoS ONE (2012)

The results of the ROI-based stepwise multiple regression analyses.7 ROIs are shown in different colors: right DLPFC  =  red, left DLPFC  =  cyan, left VLPFC  =  yellow, right TPO  =  purple, left TPO  =  green, medial parietal cortex  =  white, and left posterior IT  =  blue. The scatterplots illustrate the relationship between the psychophysical task performance scores and the FDG-uptake values in the ROIs. DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; TPO, temporo-parieto-occipital junction; posterior IT, posterior inferior temporal cortex; FDG, 18F-fluorodeoxyglucose.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369918&req=5

pone-0038498-g004: The results of the ROI-based stepwise multiple regression analyses.7 ROIs are shown in different colors: right DLPFC  =  red, left DLPFC  =  cyan, left VLPFC  =  yellow, right TPO  =  purple, left TPO  =  green, medial parietal cortex  =  white, and left posterior IT  =  blue. The scatterplots illustrate the relationship between the psychophysical task performance scores and the FDG-uptake values in the ROIs. DLPFC, dorsolateral prefrontal cortex; VLPFC, ventrolateral prefrontal cortex; TPO, temporo-parieto-occipital junction; posterior IT, posterior inferior temporal cortex; FDG, 18F-fluorodeoxyglucose.
Mentions: Subsequent stepwise multiple regression analyses were conducted using 7 ROIs; namely, the right and left dorsolateral prefrontal cortices (DLPFCs), the left ventrolateral prefrontal cortex (VLPFC), the left posterior inferior temporal cortex (posterior IT), the right and left TPOs, and the left medial parietal cortex. Reductions in CMRglc in the left VLPFC and left posterior IT were predictive of longer RTs on the Global task, whereas reductions in CMRglc in the right DLPFC and right TPO predicted longer RTs on the Local task. Hypometabolism in the right DLPFC and left posterior IT regions predicted longer RTs when performing the Mixed task. The shift cost was best predicted by hypometabolism in the right DLPFC (Table 3 and Figure 4). When the NPI depression score was added to the regression model, reduced CMRglc values in the right DLPFC and the left posterior IT cortex predicted a larger shift cost (Supplementary Table S1). The results of the regression analysis in which the NPI depression score was added to the model were otherwise the same as those of the analyses in which the NPI depression score was not included in the model.

Bottom Line: Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory.Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field.Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

ABSTRACT
The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminergic, posterior cortical pathologies may also contribute to this deficit. Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory. In this study, we attempted to identify the neural correlates of the attentional set-shifting deficit in PD using a compound letter task and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography during rest. Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field. Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.

Show MeSH
Related in: MedlinePlus