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High content screening in neurodegenerative diseases.

Jain S, van Kesteren RE, Heutink P - J Vis Exp (2012)

Bottom Line: It is expected that disease phenotypes are the result of multiple interactions that have been disrupted.This underestimation could, in part, explain the low success rate of drug approval due to undesirable or toxic side effects.This could subsequently be utilized to advance our understanding of the genome, the pathways involved in disease pathogenesis as well as identify potential therapeutic targets.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Genetics, VU University Medical Center. s.jain@vumc.nl

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Related in: MedlinePlus

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High content screening in neurodegenerative diseases.

Jain S, van Kesteren RE, Heutink P - J Vis Exp (2012)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369774&req=5

Bottom Line: It is expected that disease phenotypes are the result of multiple interactions that have been disrupted.This underestimation could, in part, explain the low success rate of drug approval due to undesirable or toxic side effects.This could subsequently be utilized to advance our understanding of the genome, the pathways involved in disease pathogenesis as well as identify potential therapeutic targets.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Genetics, VU University Medical Center. s.jain@vumc.nl

Show MeSH
Related in: MedlinePlus