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Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus

Gene relationships in GCRP pathway in diseases and TCM syndromes. GO enrichment analysis of genes in group 2 was carried out. Whether diseases (CHB or LC) and TCM syndromes (LGDHS or LDSDS) were correlated to GCRP pathway, the gene expression (upper figure) was represented that the gene expression levels were lower in CHB and higher or lower in LC. The gene network ((a), (b)) was represented that the genes connections in LDSDS (b) were more than LGDHS (a).
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fig5: Gene relationships in GCRP pathway in diseases and TCM syndromes. GO enrichment analysis of genes in group 2 was carried out. Whether diseases (CHB or LC) and TCM syndromes (LGDHS or LDSDS) were correlated to GCRP pathway, the gene expression (upper figure) was represented that the gene expression levels were lower in CHB and higher or lower in LC. The gene network ((a), (b)) was represented that the genes connections in LDSDS (b) were more than LGDHS (a).

Mentions: It was interesting in our result that the genes coexpression in group 2 was enriched in GCRP pathway. Because same situation happened to the genes in blue module, which was related with the difference between CHB and LC by the gene module analysis, these genes in GCRP pathway were differentially expressed between CHB and LC and difference coexpressed between LGDHS and LDSDS. These results were summarized in Figure 5. Interestingly, in GCRP pathway, whether TCM syndrome was LGDHS or LDSDS, the gene expression level was lower in CHB and higher or lower in LC, and whether disease was CHB or LC, the genes in LDSDS had higher correlation than LGDHS. For example, in LDSDS, genes GPER, PTHR1, GPR173, and SSTR1 were connected in a correlation network together, while they, respectively, belong to four correlation networks in LGDHS (Figure 5). These results suggested the different molecular mechanism between diseases (CHB and LC) and TCM syndromes (LGDHS and LDSDS).


Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Gene relationships in GCRP pathway in diseases and TCM syndromes. GO enrichment analysis of genes in group 2 was carried out. Whether diseases (CHB or LC) and TCM syndromes (LGDHS or LDSDS) were correlated to GCRP pathway, the gene expression (upper figure) was represented that the gene expression levels were lower in CHB and higher or lower in LC. The gene network ((a), (b)) was represented that the genes connections in LDSDS (b) were more than LGDHS (a).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369542&req=5

fig5: Gene relationships in GCRP pathway in diseases and TCM syndromes. GO enrichment analysis of genes in group 2 was carried out. Whether diseases (CHB or LC) and TCM syndromes (LGDHS or LDSDS) were correlated to GCRP pathway, the gene expression (upper figure) was represented that the gene expression levels were lower in CHB and higher or lower in LC. The gene network ((a), (b)) was represented that the genes connections in LDSDS (b) were more than LGDHS (a).
Mentions: It was interesting in our result that the genes coexpression in group 2 was enriched in GCRP pathway. Because same situation happened to the genes in blue module, which was related with the difference between CHB and LC by the gene module analysis, these genes in GCRP pathway were differentially expressed between CHB and LC and difference coexpressed between LGDHS and LDSDS. These results were summarized in Figure 5. Interestingly, in GCRP pathway, whether TCM syndrome was LGDHS or LDSDS, the gene expression level was lower in CHB and higher or lower in LC, and whether disease was CHB or LC, the genes in LDSDS had higher correlation than LGDHS. For example, in LDSDS, genes GPER, PTHR1, GPR173, and SSTR1 were connected in a correlation network together, while they, respectively, belong to four correlation networks in LGDHS (Figure 5). These results suggested the different molecular mechanism between diseases (CHB and LC) and TCM syndromes (LGDHS and LDSDS).

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus