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Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of difference expression and difference coexpression. Graph of the difference expression (a) represented that there are genes different expression levels between states A and B, and the difference coexpression (b) represented that there is higher correlation in state A and lower correlation in state B. Curves were represented as whichever genes.
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Related In: Results  -  Collection


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fig3: Schematic diagram of difference expression and difference coexpression. Graph of the difference expression (a) represented that there are genes different expression levels between states A and B, and the difference coexpression (b) represented that there is higher correlation in state A and lower correlation in state B. Curves were represented as whichever genes.

Mentions: To further demonstrate the mechanism of difference between two TCM syndromes, the correlation of gene expression including difference expression and difference coexpression was analyzed. Figure 3 was a schematic diagram which showed the meaning of difference expression or difference coexpression, respectively. The difference expression meant that there were gene different expression levels between two states. The difference coexpression meant that there was higher gene correlation in a state and lower gene correlation in another state.


Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Schematic diagram of difference expression and difference coexpression. Graph of the difference expression (a) represented that there are genes different expression levels between states A and B, and the difference coexpression (b) represented that there is higher correlation in state A and lower correlation in state B. Curves were represented as whichever genes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369542&req=5

fig3: Schematic diagram of difference expression and difference coexpression. Graph of the difference expression (a) represented that there are genes different expression levels between states A and B, and the difference coexpression (b) represented that there is higher correlation in state A and lower correlation in state B. Curves were represented as whichever genes.
Mentions: To further demonstrate the mechanism of difference between two TCM syndromes, the correlation of gene expression including difference expression and difference coexpression was analyzed. Figure 3 was a schematic diagram which showed the meaning of difference expression or difference coexpression, respectively. The difference expression meant that there were gene different expression levels between two states. The difference coexpression meant that there was higher gene correlation in a state and lower gene correlation in another state.

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus