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Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus

Average gene expression in modules which correlated with diseases or TCM syndromes. In the diseases (a), blue and brown modules both had low expression value in CHB and not consistent in LC. Yellow and turquoise modules both had high expression value in CHB and not consistent in LC. In the TCM syndromes (b), lightcyan modules had low expression value in LDSDS. Lightgreen modules had high expression value in LDSDS. A1–3 and D1–3: LDSDS; B 4, 5 and E4–6: LGDHS.
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fig2: Average gene expression in modules which correlated with diseases or TCM syndromes. In the diseases (a), blue and brown modules both had low expression value in CHB and not consistent in LC. Yellow and turquoise modules both had high expression value in CHB and not consistent in LC. In the TCM syndromes (b), lightcyan modules had low expression value in LDSDS. Lightgreen modules had high expression value in LDSDS. A1–3 and D1–3: LDSDS; B 4, 5 and E4–6: LGDHS.

Mentions: Due to the above result that the molecular mechanisms of the difference between two TCM syndromes could be not commendably explained with the single-gene difference expression method, then the gene module method was used to demonstrate the difference between diseases and TCM syndromes. The all 14352 genes were taken into 26 gene modules by the WGCNA R package [15], and each module had a name of color and a ME to identify the gene expression. Among the 26 modules, some significant modules were screened out by correlating the MEs in our disease trail or TCM syndrome trail. In the result, blue, brown, turquoise, and yellow modules were most related with the difference between CHB and LC (Figure 2(a)), and lightgreen module and lightcyan module were most related with the difference between LGDHS and LDSDS (Figure 2(b)).


Molecular Mechanisms of Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease in Chronic Hepatitis B and Liver Cirrhosis.

Guo Z, Yu S, Guan Y, Li YY, Lu YY, Zhang H, Su SB - Evid Based Complement Alternat Med (2012)

Average gene expression in modules which correlated with diseases or TCM syndromes. In the diseases (a), blue and brown modules both had low expression value in CHB and not consistent in LC. Yellow and turquoise modules both had high expression value in CHB and not consistent in LC. In the TCM syndromes (b), lightcyan modules had low expression value in LDSDS. Lightgreen modules had high expression value in LDSDS. A1–3 and D1–3: LDSDS; B 4, 5 and E4–6: LGDHS.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369542&req=5

fig2: Average gene expression in modules which correlated with diseases or TCM syndromes. In the diseases (a), blue and brown modules both had low expression value in CHB and not consistent in LC. Yellow and turquoise modules both had high expression value in CHB and not consistent in LC. In the TCM syndromes (b), lightcyan modules had low expression value in LDSDS. Lightgreen modules had high expression value in LDSDS. A1–3 and D1–3: LDSDS; B 4, 5 and E4–6: LGDHS.
Mentions: Due to the above result that the molecular mechanisms of the difference between two TCM syndromes could be not commendably explained with the single-gene difference expression method, then the gene module method was used to demonstrate the difference between diseases and TCM syndromes. The all 14352 genes were taken into 26 gene modules by the WGCNA R package [15], and each module had a name of color and a ME to identify the gene expression. Among the 26 modules, some significant modules were screened out by correlating the MEs in our disease trail or TCM syndrome trail. In the result, blue, brown, turquoise, and yellow modules were most related with the difference between CHB and LC (Figure 2(a)), and lightgreen module and lightcyan module were most related with the difference between LGDHS and LDSDS (Figure 2(b)).

Bottom Line: The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway.Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease.The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Complex System of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

ABSTRACT
Traditional Chinese medicine (TCM) treatment is based on the traditional diagnose method to distinguish the TCM syndrome, not the disease. So there is a phenomenon in the relationship between TCM syndrome and disease, called Same TCM Syndrome for Different Diseases and Different TCM Syndrome for Same Disease. In this study, we demonstrated the molecular mechanisms of this phenomenon using the microarray samples of liver-gallbladder dampness-heat syndrome (LGDHS) and liver depression and spleen deficiency syndrome (LDSDS) in the chronic hepatitis B (CHB) and liver cirrhosis (LC). The results showed that the difference between CHB and LC was gene expression level and the difference between LGDHS and LDSDS was gene coexpression in the G-protein-coupled receptor protein-signaling pathway. Therein genes GPER, PTHR1, GPR173, and SSTR1 were coexpressed in LDSDS, but not in LGDHS. Either CHB or LC was divided into the alternative LGDHS and LDSDS by the gene correlation, which reveals the molecular feature of Different TCM Syndrome for Same Disease. The alternatives LGDHS and LDSDS were divided into either CHB or LC by the gene expression level, which reveals the molecular feature of Same TCM Syndrome for Different Diseases.

No MeSH data available.


Related in: MedlinePlus