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An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear.

Cui M, McDowell EJ, Yang C - Opt Express (2010)

Bottom Line: We present a holography-based in vivo optical phase conjugation experiment performed on a living rabbit ear.We monitor the signal decay time variation after the ear is excised to postulate different mechanisms that cause the signal decay.The experimental findings address the minimum speed limit of a broad range of optical time reversal experiments for in vivo applications on tissues.

View Article: PubMed Central - PubMed

Affiliation: California Institute of Technology, Pasadena, CA 91125, USA. mcui@caltech.edu

ABSTRACT
We present a holography-based in vivo optical phase conjugation experiment performed on a living rabbit ear. The motion of live tissues caused the phase conjugate signal to decay with a consistent decay time of less than two seconds. We monitor the signal decay time variation after the ear is excised to postulate different mechanisms that cause the signal decay. The experimental findings address the minimum speed limit of a broad range of optical time reversal experiments for in vivo applications on tissues.

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(a) Top view of the experimental setup of in vivo TSOPC. The light source is a solid state CW laser at 532 nm (Spectral Physics, Excelsior). M = mirrors, WP = half wave plate for 532nm, BS = beam splitter, S1,2,3 = shutters, SH = sample holder, L = lens, CCD = CCD camera, ND = neutral density filter, Crystal = 45° cut LiNbO3 crystal. The dark arrow on top of the crystal shows the c axis of the crystal. The concentric dark ring and dot represent the vertical polarization of the laser beams. The rabbit is held on top of the crystal with a shelf which is not shown. (b) Reconstructed TSOPC images through the ear of the rabbit when it is alive (i, ii) and 30 mins after euthanasia (iii), and through a tissue phantom of comparable scattering property (iv). (c) Histology of the ear of the rabbit.
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g001: (a) Top view of the experimental setup of in vivo TSOPC. The light source is a solid state CW laser at 532 nm (Spectral Physics, Excelsior). M = mirrors, WP = half wave plate for 532nm, BS = beam splitter, S1,2,3 = shutters, SH = sample holder, L = lens, CCD = CCD camera, ND = neutral density filter, Crystal = 45° cut LiNbO3 crystal. The dark arrow on top of the crystal shows the c axis of the crystal. The concentric dark ring and dot represent the vertical polarization of the laser beams. The rabbit is held on top of the crystal with a shelf which is not shown. (b) Reconstructed TSOPC images through the ear of the rabbit when it is alive (i, ii) and 30 mins after euthanasia (iii), and through a tissue phantom of comparable scattering property (iv). (c) Histology of the ear of the rabbit.

Mentions: Figure 1(a)Fig. 1


An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit ear.

Cui M, McDowell EJ, Yang C - Opt Express (2010)

(a) Top view of the experimental setup of in vivo TSOPC. The light source is a solid state CW laser at 532 nm (Spectral Physics, Excelsior). M = mirrors, WP = half wave plate for 532nm, BS = beam splitter, S1,2,3 = shutters, SH = sample holder, L = lens, CCD = CCD camera, ND = neutral density filter, Crystal = 45° cut LiNbO3 crystal. The dark arrow on top of the crystal shows the c axis of the crystal. The concentric dark ring and dot represent the vertical polarization of the laser beams. The rabbit is held on top of the crystal with a shelf which is not shown. (b) Reconstructed TSOPC images through the ear of the rabbit when it is alive (i, ii) and 30 mins after euthanasia (iii), and through a tissue phantom of comparable scattering property (iv). (c) Histology of the ear of the rabbit.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369536&req=5

g001: (a) Top view of the experimental setup of in vivo TSOPC. The light source is a solid state CW laser at 532 nm (Spectral Physics, Excelsior). M = mirrors, WP = half wave plate for 532nm, BS = beam splitter, S1,2,3 = shutters, SH = sample holder, L = lens, CCD = CCD camera, ND = neutral density filter, Crystal = 45° cut LiNbO3 crystal. The dark arrow on top of the crystal shows the c axis of the crystal. The concentric dark ring and dot represent the vertical polarization of the laser beams. The rabbit is held on top of the crystal with a shelf which is not shown. (b) Reconstructed TSOPC images through the ear of the rabbit when it is alive (i, ii) and 30 mins after euthanasia (iii), and through a tissue phantom of comparable scattering property (iv). (c) Histology of the ear of the rabbit.
Mentions: Figure 1(a)Fig. 1

Bottom Line: We present a holography-based in vivo optical phase conjugation experiment performed on a living rabbit ear.We monitor the signal decay time variation after the ear is excised to postulate different mechanisms that cause the signal decay.The experimental findings address the minimum speed limit of a broad range of optical time reversal experiments for in vivo applications on tissues.

View Article: PubMed Central - PubMed

Affiliation: California Institute of Technology, Pasadena, CA 91125, USA. mcui@caltech.edu

ABSTRACT
We present a holography-based in vivo optical phase conjugation experiment performed on a living rabbit ear. The motion of live tissues caused the phase conjugate signal to decay with a consistent decay time of less than two seconds. We monitor the signal decay time variation after the ear is excised to postulate different mechanisms that cause the signal decay. The experimental findings address the minimum speed limit of a broad range of optical time reversal experiments for in vivo applications on tissues.

Show MeSH
Related in: MedlinePlus