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A new piezoelectric actuator induces bone formation in vivo: a preliminary study.

Reis J, Frias C, Canto e Castro C, Botelho ML, Marques AT, Simões JA, Capela e Silva F, Potes J - J. Biomed. Biotechnol. (2012)

Bottom Line: After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls.Bone deposition rate was also significantly higher in the mechanically stimulated areas.The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Medicina Veterinária, Universidade de Évora, 7002-554 Évora, Portugal.

ABSTRACT
This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, through Masson's trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.

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Related in: MedlinePlus

Postoperative radiograph thirty days after implantation showing the six actuators in place (four in the femur, two in the tibia). There are neither signs of periostal or peri-implantar reaction nor signs of infection in neighboring soft tissues.
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Related In: Results  -  Collection


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fig2: Postoperative radiograph thirty days after implantation showing the six actuators in place (four in the femur, two in the tibia). There are neither signs of periostal or peri-implantar reaction nor signs of infection in neighboring soft tissues.

Mentions: Postoperative X-ray images were obtained thirty days after implantation, before sacrifice, to ensure the proper evolution of the bone cuts and to detect signs of infection/inflammation (Figure 2).


A new piezoelectric actuator induces bone formation in vivo: a preliminary study.

Reis J, Frias C, Canto e Castro C, Botelho ML, Marques AT, Simões JA, Capela e Silva F, Potes J - J. Biomed. Biotechnol. (2012)

Postoperative radiograph thirty days after implantation showing the six actuators in place (four in the femur, two in the tibia). There are neither signs of periostal or peri-implantar reaction nor signs of infection in neighboring soft tissues.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369535&req=5

fig2: Postoperative radiograph thirty days after implantation showing the six actuators in place (four in the femur, two in the tibia). There are neither signs of periostal or peri-implantar reaction nor signs of infection in neighboring soft tissues.
Mentions: Postoperative X-ray images were obtained thirty days after implantation, before sacrifice, to ensure the proper evolution of the bone cuts and to detect signs of infection/inflammation (Figure 2).

Bottom Line: After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls.Bone deposition rate was also significantly higher in the mechanically stimulated areas.The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Medicina Veterinária, Universidade de Évora, 7002-554 Évora, Portugal.

ABSTRACT
This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, through Masson's trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.

Show MeSH
Related in: MedlinePlus