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Relationship between Blood Stasis Syndrome Score and Cardioankle Vascular Index in Stroke Patients.

Cho KH, Kim KP, Woo BC, Kim YJ, Park JY, Cho SY, Park SU, Jung WS, Park JM, Moon SK - Evid Based Complement Alternat Med (2012)

Bottom Line: The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP).Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, P = 0.032) after adjusting for the age and SBP.The AUC of the "CAVI+Age," which was calculated by combining CAVI with age, showed better accuracy (0.759, P < 0.0001) than those of CAVI or age.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea.

ABSTRACT
Blood stasis syndrome (BSS) in traditional Asian medicine has been considered to correlate with the extent of atherosclerosis, which can be estimated using the cardioankle vascular index (CAVI). Here, the diagnostic utility of CAVI in predicting BSS was examined. The BSS scores and CAVI were measured in 140 stroke patients and evaluated with respect to stroke risk factors. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic accuracy of CAVI for the diagnosis of BSS. The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP). Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, P = 0.032) after adjusting for the age and SBP. The ROC curve showed that CAVI and age provided moderate diagnostic accuracy for BSS (area under the ROC curve (AUC) for CAVI, 0.703, P < 0.001; AUC for age, 0.692, P = 0.001). The AUC of the "CAVI+Age," which was calculated by combining CAVI with age, showed better accuracy (0.759, P < 0.0001) than those of CAVI or age. The present study suggests that the CAVI combined with age can clinically serve as an objective tool to diagnose BSS in stroke patients.

No MeSH data available.


Related in: MedlinePlus

The diagnostic accuracy of the systolic blood pressure (SBP), age, CAVI, and CAVI+Age for predicting blood stasis syndrome (BSS) in stroke patients. The ROC curves depicted that the CAVI and age showed modest diagnostic utility for BSS with the CAVI+Age indicating good diagnostic accuracy, while SBP provided poor diagnostic utility. In each graph, the solid diagonal line was the line of no discrimination (area = 0.5), and the optimal cut-off points were indicated on the curves.
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fig2: The diagnostic accuracy of the systolic blood pressure (SBP), age, CAVI, and CAVI+Age for predicting blood stasis syndrome (BSS) in stroke patients. The ROC curves depicted that the CAVI and age showed modest diagnostic utility for BSS with the CAVI+Age indicating good diagnostic accuracy, while SBP provided poor diagnostic utility. In each graph, the solid diagonal line was the line of no discrimination (area = 0.5), and the optimal cut-off points were indicated on the curves.

Mentions: ROC curves were generated for CAVI, age, and SBP to determine their possible diagnostic utility for distinguishing the BSS groups from the non-BSS groups (Figure 2). The CAVI and age showed modest utility with ROC curves that were higher and shifted more to the left than those of SBP, which showed poor utility. Based on the area under the ROC curve (AUC), by which the accuracy of the test is measured, the AUC of the CAVI and age showed average accuracy (0.703 and 0.692, resp.), with no significant difference between these values. However, the SBP indicated an AUC of 0.630, which did not reject the hypothesis (true area = 0.50) (Table 4). To find a better discriminator of BSS, a new variable “CAVI+Age” was calculated by combining the CAVI with age as follows: the age was categorized into ages <40, 40–49, 50–59, 60–69, and ≥70; then converted into 1, 2, 3, 4, and 5, respectively; finally added to CAVI scores. The AUC of the “CAVI+Age” (0.759) showed better accuracy than those of the CAVI or age although there was no significant difference among those values (Table 4) (Figure 2).


Relationship between Blood Stasis Syndrome Score and Cardioankle Vascular Index in Stroke Patients.

Cho KH, Kim KP, Woo BC, Kim YJ, Park JY, Cho SY, Park SU, Jung WS, Park JM, Moon SK - Evid Based Complement Alternat Med (2012)

The diagnostic accuracy of the systolic blood pressure (SBP), age, CAVI, and CAVI+Age for predicting blood stasis syndrome (BSS) in stroke patients. The ROC curves depicted that the CAVI and age showed modest diagnostic utility for BSS with the CAVI+Age indicating good diagnostic accuracy, while SBP provided poor diagnostic utility. In each graph, the solid diagonal line was the line of no discrimination (area = 0.5), and the optimal cut-off points were indicated on the curves.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369533&req=5

fig2: The diagnostic accuracy of the systolic blood pressure (SBP), age, CAVI, and CAVI+Age for predicting blood stasis syndrome (BSS) in stroke patients. The ROC curves depicted that the CAVI and age showed modest diagnostic utility for BSS with the CAVI+Age indicating good diagnostic accuracy, while SBP provided poor diagnostic utility. In each graph, the solid diagonal line was the line of no discrimination (area = 0.5), and the optimal cut-off points were indicated on the curves.
Mentions: ROC curves were generated for CAVI, age, and SBP to determine their possible diagnostic utility for distinguishing the BSS groups from the non-BSS groups (Figure 2). The CAVI and age showed modest utility with ROC curves that were higher and shifted more to the left than those of SBP, which showed poor utility. Based on the area under the ROC curve (AUC), by which the accuracy of the test is measured, the AUC of the CAVI and age showed average accuracy (0.703 and 0.692, resp.), with no significant difference between these values. However, the SBP indicated an AUC of 0.630, which did not reject the hypothesis (true area = 0.50) (Table 4). To find a better discriminator of BSS, a new variable “CAVI+Age” was calculated by combining the CAVI with age as follows: the age was categorized into ages <40, 40–49, 50–59, 60–69, and ≥70; then converted into 1, 2, 3, 4, and 5, respectively; finally added to CAVI scores. The AUC of the “CAVI+Age” (0.759) showed better accuracy than those of the CAVI or age although there was no significant difference among those values (Table 4) (Figure 2).

Bottom Line: The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP).Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, P = 0.032) after adjusting for the age and SBP.The AUC of the "CAVI+Age," which was calculated by combining CAVI with age, showed better accuracy (0.759, P < 0.0001) than those of CAVI or age.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea.

ABSTRACT
Blood stasis syndrome (BSS) in traditional Asian medicine has been considered to correlate with the extent of atherosclerosis, which can be estimated using the cardioankle vascular index (CAVI). Here, the diagnostic utility of CAVI in predicting BSS was examined. The BSS scores and CAVI were measured in 140 stroke patients and evaluated with respect to stroke risk factors. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic accuracy of CAVI for the diagnosis of BSS. The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP). Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, P = 0.032) after adjusting for the age and SBP. The ROC curve showed that CAVI and age provided moderate diagnostic accuracy for BSS (area under the ROC curve (AUC) for CAVI, 0.703, P < 0.001; AUC for age, 0.692, P = 0.001). The AUC of the "CAVI+Age," which was calculated by combining CAVI with age, showed better accuracy (0.759, P < 0.0001) than those of CAVI or age. The present study suggests that the CAVI combined with age can clinically serve as an objective tool to diagnose BSS in stroke patients.

No MeSH data available.


Related in: MedlinePlus