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Surgical Resection for Small Cell Lung Cancer: Pneumonectomy versus Lobectomy.

Yuequan J, Zhi Z, Chenmin X - ISRN Surg (2012)

Bottom Line: Background.Local recurrence rate and survival rate according to surgical procedures and cancer stages were analyzed.Results.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Chongqing Cancer Institute, Shapingba District, Hanyu Avenue, Chongqing 400030, China.

ABSTRACT
Background. There are some patients with SCLC that are diagnosed in the operating room by cryosection and surgeons had to perform surgical resection for these patients. The aim of this study is to compare the effective of pneumonectomy with lobectomy for SCLC. Methods. A retrospective study was undertaken in 75 patients with SCLC that were diagnosed by cryosection during surgery. 31 of them underwent pneumonectomy, 44 underwent lobectomy. Local recurrence rate and survival rate according to surgical procedures and cancer stages were analyzed. Results. There was significant difference in the overall survival rate between lobectomy and pneumonectomy groups (P = 0.044). For patients with stage II SCLC, the overall survival rate after pneumonectomy was significantly better than after lobectomy (P = 0.028). No significant difference in overall survival rate was found between the two surgical groups in patients with stage III SCLC (P = 0.933). The local recurrence rate in lobectomy group was significant higher that in pneumonectomy group (P = 0.0017). Conclusions. SCLC was responsive to surgical therapy. When surgeons have to select an appropriate method of operation for patients with SCLC during surgery, pneumonectomy may be the right choice for these patients. Pneumonectomy can result in significantly better local control and higher survival rate compare with lobectomy.

No MeSH data available.


Related in: MedlinePlus

Survival curves of patients with stag III SCLC according to surgical procedures. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC.
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fig3: Survival curves of patients with stag III SCLC according to surgical procedures. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC.

Mentions: The median survival time and 5-year survival rate of patients with stage II SCLC were 22 months and 16.7% in lobectomy group, 30 months and 31.6% in the pneumonectomy group. For patients with stage II SCLC, the overall survival rate after pneumonectomy was significantly better than after lobectomy (P = 0.028, Figure 2). For patients with stage III SCLC, the median survival time was 16 months in lobectomy group and 18 months in pneumonectomy group respectively. There was no patient with stage III SCLC who survived for more than 5 years in this study. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC (P = 0.933, Figure 3).


Surgical Resection for Small Cell Lung Cancer: Pneumonectomy versus Lobectomy.

Yuequan J, Zhi Z, Chenmin X - ISRN Surg (2012)

Survival curves of patients with stag III SCLC according to surgical procedures. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369481&req=5

fig3: Survival curves of patients with stag III SCLC according to surgical procedures. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC.
Mentions: The median survival time and 5-year survival rate of patients with stage II SCLC were 22 months and 16.7% in lobectomy group, 30 months and 31.6% in the pneumonectomy group. For patients with stage II SCLC, the overall survival rate after pneumonectomy was significantly better than after lobectomy (P = 0.028, Figure 2). For patients with stage III SCLC, the median survival time was 16 months in lobectomy group and 18 months in pneumonectomy group respectively. There was no patient with stage III SCLC who survived for more than 5 years in this study. No significant difference in overall survival rate was found between lobectomy group and pneumonectomy group in patients with stage III SCLC (P = 0.933, Figure 3).

Bottom Line: Background.Local recurrence rate and survival rate according to surgical procedures and cancer stages were analyzed.Results.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Chongqing Cancer Institute, Shapingba District, Hanyu Avenue, Chongqing 400030, China.

ABSTRACT
Background. There are some patients with SCLC that are diagnosed in the operating room by cryosection and surgeons had to perform surgical resection for these patients. The aim of this study is to compare the effective of pneumonectomy with lobectomy for SCLC. Methods. A retrospective study was undertaken in 75 patients with SCLC that were diagnosed by cryosection during surgery. 31 of them underwent pneumonectomy, 44 underwent lobectomy. Local recurrence rate and survival rate according to surgical procedures and cancer stages were analyzed. Results. There was significant difference in the overall survival rate between lobectomy and pneumonectomy groups (P = 0.044). For patients with stage II SCLC, the overall survival rate after pneumonectomy was significantly better than after lobectomy (P = 0.028). No significant difference in overall survival rate was found between the two surgical groups in patients with stage III SCLC (P = 0.933). The local recurrence rate in lobectomy group was significant higher that in pneumonectomy group (P = 0.0017). Conclusions. SCLC was responsive to surgical therapy. When surgeons have to select an appropriate method of operation for patients with SCLC during surgery, pneumonectomy may be the right choice for these patients. Pneumonectomy can result in significantly better local control and higher survival rate compare with lobectomy.

No MeSH data available.


Related in: MedlinePlus