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Assessment of carotid arterial wall elasticity in type 2 diabetes mellitus patients with microalbuminuria by real-time ultrasound elastography.

Zhang YH, Gao Y, Su BL - Int J Endocrinol (2012)

Bottom Line: The mean SR value ± SD of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05).SR was positively and significantly correlated with UAE, HbA1c, and systolic blood pressure (r = 0.456,0.435,0.235, P < 0.05 for all).The mean value ± SD of UAE, HbA1c, 2hPG, BMI, and TC of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05 for all).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.

ABSTRACT
The aim of this study was to evaluate carotid arterial wall elasticity in type 2 diabetes mellitus (T2DM) with microalbuminuria by real-time ultrasound elastography. Two hundred and ten T2DM patients were divided into two groups according to levels of urinary albumin excretion (UAE): T2DM without microalbuminuria (T2DM1 group, 120) and T2DM with microalbuminuria (T2DM2 group, 90). The right common carotid arteries were examined by real-time ultrasound elastography. The strain ratio (SR, blood to arterial wall strain ratio) was calculated by dividing the strain value of the blood by that of the carotid arterial wall. The correlation between SR and general data was analyzed. The mean SR value ± SD of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05). SR was positively and significantly correlated with UAE, HbA1c, and systolic blood pressure (r = 0.456,0.435,0.235, P < 0.05 for all). The mean value ± SD of UAE, HbA1c, 2hPG, BMI, and TC of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05 for all). In conclusion, there is an association between microalbuminuria and carotid arterial wall elasticity in T2DM patients.

No MeSH data available.


Related in: MedlinePlus

Longitudinal carotid artery image obtained in T2DM2 group on real-time US elastography. The left image shows the elastographic image in different colors representing different levels of strain. The right image shows the positions of ROI (A) and ROI (B), and the strain ratio (blood to carotid arterial wall strain ratio) as 2.40, calculated as the blood strain (B, 0.44%) divided by the arterial wall strain (A, 0.19%).
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fig2: Longitudinal carotid artery image obtained in T2DM2 group on real-time US elastography. The left image shows the elastographic image in different colors representing different levels of strain. The right image shows the positions of ROI (A) and ROI (B), and the strain ratio (blood to carotid arterial wall strain ratio) as 2.40, calculated as the blood strain (B, 0.44%) divided by the arterial wall strain (A, 0.19%).

Mentions: During the 24-month study period, 210 consecutive T2DM patients with or without microalbuminuria were screened. The characteristics of the 210 enrolled patients are shown in Table 1. The mean SR value ± SD of T2DM2 group (1.56 ± 0.45) was significantly higher than that of T2DM1 group (1.10 ± 0.24, P < 0.05) (Figures 1 and 2, Table 1). The mean values ± SD of 2hPG, BMI, TC, UAE, and HbA1c of T2DM2 group were significantly higher than those of T2DM1 group (P < 0.05 for all) (Table 1). There were no significant difference in systolic blood pressure, diastolic blood pressure, TG, LDL, HDL, FPG between T2DM1 and T2DM2 groups (P > 0.05 for all) (Table 1). In univariate analysis, SR was positively and significantly associated with UAE (r = 0.456, P < 0.05) and HbA1c (r = 0.435, P < 0.05), systolic blood pressure (r = 0.235, P < 0.05).


Assessment of carotid arterial wall elasticity in type 2 diabetes mellitus patients with microalbuminuria by real-time ultrasound elastography.

Zhang YH, Gao Y, Su BL - Int J Endocrinol (2012)

Longitudinal carotid artery image obtained in T2DM2 group on real-time US elastography. The left image shows the elastographic image in different colors representing different levels of strain. The right image shows the positions of ROI (A) and ROI (B), and the strain ratio (blood to carotid arterial wall strain ratio) as 2.40, calculated as the blood strain (B, 0.44%) divided by the arterial wall strain (A, 0.19%).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369475&req=5

fig2: Longitudinal carotid artery image obtained in T2DM2 group on real-time US elastography. The left image shows the elastographic image in different colors representing different levels of strain. The right image shows the positions of ROI (A) and ROI (B), and the strain ratio (blood to carotid arterial wall strain ratio) as 2.40, calculated as the blood strain (B, 0.44%) divided by the arterial wall strain (A, 0.19%).
Mentions: During the 24-month study period, 210 consecutive T2DM patients with or without microalbuminuria were screened. The characteristics of the 210 enrolled patients are shown in Table 1. The mean SR value ± SD of T2DM2 group (1.56 ± 0.45) was significantly higher than that of T2DM1 group (1.10 ± 0.24, P < 0.05) (Figures 1 and 2, Table 1). The mean values ± SD of 2hPG, BMI, TC, UAE, and HbA1c of T2DM2 group were significantly higher than those of T2DM1 group (P < 0.05 for all) (Table 1). There were no significant difference in systolic blood pressure, diastolic blood pressure, TG, LDL, HDL, FPG between T2DM1 and T2DM2 groups (P > 0.05 for all) (Table 1). In univariate analysis, SR was positively and significantly associated with UAE (r = 0.456, P < 0.05) and HbA1c (r = 0.435, P < 0.05), systolic blood pressure (r = 0.235, P < 0.05).

Bottom Line: The mean SR value ± SD of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05).SR was positively and significantly correlated with UAE, HbA1c, and systolic blood pressure (r = 0.456,0.435,0.235, P < 0.05 for all).The mean value ± SD of UAE, HbA1c, 2hPG, BMI, and TC of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05 for all).

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Ultrasound, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.

ABSTRACT
The aim of this study was to evaluate carotid arterial wall elasticity in type 2 diabetes mellitus (T2DM) with microalbuminuria by real-time ultrasound elastography. Two hundred and ten T2DM patients were divided into two groups according to levels of urinary albumin excretion (UAE): T2DM without microalbuminuria (T2DM1 group, 120) and T2DM with microalbuminuria (T2DM2 group, 90). The right common carotid arteries were examined by real-time ultrasound elastography. The strain ratio (SR, blood to arterial wall strain ratio) was calculated by dividing the strain value of the blood by that of the carotid arterial wall. The correlation between SR and general data was analyzed. The mean SR value ± SD of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05). SR was positively and significantly correlated with UAE, HbA1c, and systolic blood pressure (r = 0.456,0.435,0.235, P < 0.05 for all). The mean value ± SD of UAE, HbA1c, 2hPG, BMI, and TC of T2DM2 group was significantly higher than that of T2DM1 group (P < 0.05 for all). In conclusion, there is an association between microalbuminuria and carotid arterial wall elasticity in T2DM patients.

No MeSH data available.


Related in: MedlinePlus