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Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus

The improvement in wound size and Wagner grades of three patients in the WH-1 cream group. (a) Before WH-1 cream treatment, (b) the 14th day after treatment.
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fig3: The improvement in wound size and Wagner grades of three patients in the WH-1 cream group. (a) Before WH-1 cream treatment, (b) the 14th day after treatment.

Mentions: After 2 weeks of treatment, 4 (36.4%) patients had Wagner grades 2 and 6 (54.6%) patients had Wagner grade 1 in the WH-1 cream group; 4 (40.0%) patients had Wagner grade 2 and 3 (30.0%) patients had Wagner grade 1 in the hydrocolloid fiber dressing group. The secondary endpoint was the proportion of patients who had improvements in Wagner grade, and improvement in the WH-1 group (10 of 11 patients, 90.9%) was slightly higher than that in the hydrocolloid fiber dressing group (7 of 10 patients, 70.0%), but the difference was not statistically significant (P = 0.311). Figure 3 shows photographs demonstrating improvements in wound size and Wagner grades of the WH-1 cream group.


Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

The improvement in wound size and Wagner grades of three patients in the WH-1 cream group. (a) Before WH-1 cream treatment, (b) the 14th day after treatment.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369464&req=5

fig3: The improvement in wound size and Wagner grades of three patients in the WH-1 cream group. (a) Before WH-1 cream treatment, (b) the 14th day after treatment.
Mentions: After 2 weeks of treatment, 4 (36.4%) patients had Wagner grades 2 and 6 (54.6%) patients had Wagner grade 1 in the WH-1 cream group; 4 (40.0%) patients had Wagner grade 2 and 3 (30.0%) patients had Wagner grade 1 in the hydrocolloid fiber dressing group. The secondary endpoint was the proportion of patients who had improvements in Wagner grade, and improvement in the WH-1 group (10 of 11 patients, 90.9%) was slightly higher than that in the hydrocolloid fiber dressing group (7 of 10 patients, 70.0%), but the difference was not statistically significant (P = 0.311). Figure 3 shows photographs demonstrating improvements in wound size and Wagner grades of the WH-1 cream group.

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus