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Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus

Changes of wound size.
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Related In: Results  -  Collection


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fig2: Changes of wound size.

Mentions: The ITT population comprised 21 patients; 11 patients treated with WH-1 and 10 patients treated with hydrocolloid fiber dressing. The primary endpoint, percent changes in wound size from baseline at the final visit (day 14, end week 2) in the ITT population are shown in Table 2. No statistically significant differences were found in the percent changes in wound size between the WH-1 cream and hydrocolloid fiber dressing groups (P = 0.673). Analysis of results within treatment groups showed that only the hydrocolloid fiber dressing group had significant decreases in wound sizes from baseline to the final visit (P = 0.037, Figure 2).


Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

Changes of wound size.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369464&req=5

fig2: Changes of wound size.
Mentions: The ITT population comprised 21 patients; 11 patients treated with WH-1 and 10 patients treated with hydrocolloid fiber dressing. The primary endpoint, percent changes in wound size from baseline at the final visit (day 14, end week 2) in the ITT population are shown in Table 2. No statistically significant differences were found in the percent changes in wound size between the WH-1 cream and hydrocolloid fiber dressing groups (P = 0.673). Analysis of results within treatment groups showed that only the hydrocolloid fiber dressing group had significant decreases in wound sizes from baseline to the final visit (P = 0.037, Figure 2).

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus