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Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus

Patients' flow chart.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Patients' flow chart.

Mentions: A total of 24 patients were screened and enrolled into the study between October 29, 2008 and December 14, 2010. Of these, 12 patients were randomly assigned to the WH-1 cream group and 12 patients to the hydrocolloid fiber dressing group. No participants were excluded during screening. Figure 1 shows a flow chart of the trial that presents the reasons for early termination and protocol violations in detail. Only one patient in the hydrocolloid fiber dressing group did not complete the study because the patient withdrew consent and decided to receive full-thickness skin grafts. Two other patients (1 in WH-1 group and 1 in hydrocolloid fiber dressing group) were protocol violating because their ulcers were not Wagner grade 3 at enrollment.


Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers.

Kuo YS, Chien HF, Lu W - Evid Based Complement Alternat Med (2012)

Patients' flow chart.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3369464&req=5

fig1: Patients' flow chart.
Mentions: A total of 24 patients were screened and enrolled into the study between October 29, 2008 and December 14, 2010. Of these, 12 patients were randomly assigned to the WH-1 cream group and 12 patients to the hydrocolloid fiber dressing group. No participants were excluded during screening. Figure 1 shows a flow chart of the trial that presents the reasons for early termination and protocol violations in detail. Only one patient in the hydrocolloid fiber dressing group did not complete the study because the patient withdrew consent and decided to receive full-thickness skin grafts. Two other patients (1 in WH-1 group and 1 in hydrocolloid fiber dressing group) were protocol violating because their ulcers were not Wagner grade 3 at enrollment.

Bottom Line: Wound condition and safety were assessed at days 7 and 14 and results were compared between groups.A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance.For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.

ABSTRACT
Effects of a topical cream containing P. amboinicus (Lour.) Spreng. (Lamiaceae) and C. asiatica (L.) Urban (Umbelliferae) were evaluated and compared to effects of hydrocolloid fiber wound dressing for diabetic foot ulcers. A single-center, randomized, controlled, open-label study was conducted. Twenty-four type 1 or type 2 diabetes patients aged 20 years or older with Wagner grade 3 foot ulcers postsurgical debridement were enrolled between October 2008 and December 2009. Twelve randomly assigned patients were treated with WH-1 cream containing P. amboinicus and C. asiatica twice daily for two weeks. Another 12 patients were treated with hydrocolloid fiber dressings changed at 7 days or when clinically indicated. Wound condition and safety were assessed at days 7 and 14 and results were compared between groups. No statistically significant differences were seen in percent changes in wound size at 7- and 14-day assessments of WH-1 cream and hydrocolloid dressing groups. A slightly higher proportion of patients in the WH-1 cream group (10 of 12; 90.9%) showed Wagner grade improvement compared to the hydrocolloid fiber dressing group but without statistical significance. For treating diabetic foot ulcers, P. amboinicus and C. asiatica cream is a safe alternative to hydrocolloid fiber dressing without significant difference in effectiveness.

No MeSH data available.


Related in: MedlinePlus