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Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.

Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC - J. Korean Med. Sci. (2012)

Bottom Line: Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001).Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66).In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

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Related in: MedlinePlus

Association between log-transformed OHVD levels and various outcome variables by generalized additive mixed models adjusted for age, sex, smoking, drinking, regular exercise, diabetes, hypertension, dyslipidemia, 7-day moving average for sunshine amount of Seongbuk-gu from the day each subject visited. BMI, body mass index; TG, triglyceride; HDL cholesterol, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance index; SBP, systolic blood pressure; DBP, diastolic blood pressure; log(25(OH)D), log-transformed 25-hydroxyvitamin D.
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Figure 1: Association between log-transformed OHVD levels and various outcome variables by generalized additive mixed models adjusted for age, sex, smoking, drinking, regular exercise, diabetes, hypertension, dyslipidemia, 7-day moving average for sunshine amount of Seongbuk-gu from the day each subject visited. BMI, body mass index; TG, triglyceride; HDL cholesterol, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance index; SBP, systolic blood pressure; DBP, diastolic blood pressure; log(25(OH)D), log-transformed 25-hydroxyvitamin D.

Mentions: Effects of serum OHVD levels on continuous variables (BMI, TG, HDL cholesterol, glucose, insulin, HOMA-IR, SBP, and DBP) across differently adjusted models were analyzed by mixed model analysis, and are shown in Table 4. Significant inverse relationship with serum OHVD levels were found with TG, insulin, HOMA-IR, SBP and DBP across all three models, but no significance was found with BMI, HDL cholesterol and glucose in any of the models. Results were consistent in direction and significance across all the selected moving average for amount of sunshine, and the effect size was greatest at lag 0-7. To confirm for the linear association between log-transformed OHVD levels and various outcome variables in the mixed model analysis, we implemented generalized additive mixed models, as shown in Fig. 1 (14).


Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.

Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC - J. Korean Med. Sci. (2012)

Association between log-transformed OHVD levels and various outcome variables by generalized additive mixed models adjusted for age, sex, smoking, drinking, regular exercise, diabetes, hypertension, dyslipidemia, 7-day moving average for sunshine amount of Seongbuk-gu from the day each subject visited. BMI, body mass index; TG, triglyceride; HDL cholesterol, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance index; SBP, systolic blood pressure; DBP, diastolic blood pressure; log(25(OH)D), log-transformed 25-hydroxyvitamin D.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369452&req=5

Figure 1: Association between log-transformed OHVD levels and various outcome variables by generalized additive mixed models adjusted for age, sex, smoking, drinking, regular exercise, diabetes, hypertension, dyslipidemia, 7-day moving average for sunshine amount of Seongbuk-gu from the day each subject visited. BMI, body mass index; TG, triglyceride; HDL cholesterol, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance index; SBP, systolic blood pressure; DBP, diastolic blood pressure; log(25(OH)D), log-transformed 25-hydroxyvitamin D.
Mentions: Effects of serum OHVD levels on continuous variables (BMI, TG, HDL cholesterol, glucose, insulin, HOMA-IR, SBP, and DBP) across differently adjusted models were analyzed by mixed model analysis, and are shown in Table 4. Significant inverse relationship with serum OHVD levels were found with TG, insulin, HOMA-IR, SBP and DBP across all three models, but no significance was found with BMI, HDL cholesterol and glucose in any of the models. Results were consistent in direction and significance across all the selected moving average for amount of sunshine, and the effect size was greatest at lag 0-7. To confirm for the linear association between log-transformed OHVD levels and various outcome variables in the mixed model analysis, we implemented generalized additive mixed models, as shown in Fig. 1 (14).

Bottom Line: Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001).Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66).In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

Show MeSH
Related in: MedlinePlus