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Endothelial dysfunction and increased carotid intima-media thickness in the patients with slow coronary flow.

Yoon HJ, Jeong MH, Cho SH, Kim KH, Lee MG, Park KH, Sim DS, Yoon NS, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC - J. Korean Med. Sci. (2012)

Bottom Line: Heart rate was higher in group II than in group I.White blood cells, especially monocytes and homocysteine were higher in group II.The FMD was significantly lower in group II than in group I.

View Article: PubMed Central - PubMed

Affiliation: The Heart Center of Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 ± 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 ± 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow.

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Receiver operator characteristics curves of slow coronary flow. Arrow means cut off value of FMD (Area under the curve = 0.787, sensitivity = 0.773, specificity = 0.732).
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Figure 2: Receiver operator characteristics curves of slow coronary flow. Arrow means cut off value of FMD (Area under the curve = 0.787, sensitivity = 0.773, specificity = 0.732).

Mentions: In regression analysis, elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis (Table 4). The cut off value of FMD for prediction of slow flow was 6.97% (area under the curve = 0.787, sensitivity = 77.3%, specificity = 73.2%) (Fig. 2).


Endothelial dysfunction and increased carotid intima-media thickness in the patients with slow coronary flow.

Yoon HJ, Jeong MH, Cho SH, Kim KH, Lee MG, Park KH, Sim DS, Yoon NS, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC - J. Korean Med. Sci. (2012)

Receiver operator characteristics curves of slow coronary flow. Arrow means cut off value of FMD (Area under the curve = 0.787, sensitivity = 0.773, specificity = 0.732).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369446&req=5

Figure 2: Receiver operator characteristics curves of slow coronary flow. Arrow means cut off value of FMD (Area under the curve = 0.787, sensitivity = 0.773, specificity = 0.732).
Mentions: In regression analysis, elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis (Table 4). The cut off value of FMD for prediction of slow flow was 6.97% (area under the curve = 0.787, sensitivity = 77.3%, specificity = 73.2%) (Fig. 2).

Bottom Line: Heart rate was higher in group II than in group I.White blood cells, especially monocytes and homocysteine were higher in group II.The FMD was significantly lower in group II than in group I.

View Article: PubMed Central - PubMed

Affiliation: The Heart Center of Chonnam National University Hospital, Gwangju, Korea.

ABSTRACT
Flow mediated brachial dilatation (FMD) and carotid intima-media thickness (IMT) have been a surrogate for early atherosclerosis. Slow coronary flow in a normal coronary angiogram is not a rare condition, but its pathogenesis remains unclear. A total of 85 patients with angina were evaluated of their brachial artery FMD, carotid IMT and conventional coronary angiography. Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count method. Group I was a control with normal coronary angiography (n = 41, 56.1 ± 8.0 yr) and group II was no significant coronary stenosis with slow flow (n = 44, 56.3 ± 10.0 yr). Diabetes was rare but dyslipidemia and family history were frequent in group II. Heart rate was higher in group II than in group I. White blood cells, especially monocytes and homocysteine were higher in group II. The FMD was significantly lower in group II than in group I. Elevated heart rate, dyslipidemia and low FMD were independently related with slow coronary flow in regression analysis. Therefore, endothelial dysfunction may be an earlier vascular phenomenon than increased carotid IMT in the patients with slow coronary flow.

Show MeSH
Related in: MedlinePlus