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Diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue lymphoma arising in a female urethra treated with rituximab for the first time.

Zahrani AA, Abdelsalam M, Fiaar AA, Ibrahim N, Al-Elawi A, Muhammad B - Case Rep Oncol (2012)

Bottom Line: Pathological examination revealed non-Hodgkin's lymphoma of diffuse large B-cell type and mucosa-associated lymphoid tissue type, stage IE.Patient follow-up was done 3 months later through CT scan and cytoscopy confirming the complete remission.The patient has been disease-free for 4 years.

View Article: PubMed Central - PubMed

Affiliation: Oncology Department, Riyadh Military Hospital, Riyadh, Kingdom of Saudi Arabia.

ABSTRACT
A 30-year-old female patient presented to the gynecology clinic with a small (painless) swelling at the urethral orifice. She underwent surgical excision of the lesion. Pathological examination revealed non-Hodgkin's lymphoma of diffuse large B-cell type and mucosa-associated lymphoid tissue type, stage IE. The patient refused radiotherapy. Accordingly, we started CHOP-R chemotherapy. She received a total of 6 cycles of CHOP and 8 cycles of rituximab. Patient follow-up was done 3 months later through CT scan and cytoscopy confirming the complete remission. The patient has been disease-free for 4 years. We reviewed 26 cases of this rare entity reported previously.

No MeSH data available.


Related in: MedlinePlus

Diffuse proliferation of malignant ltmphoid cells (hematoxylin and eosin, ×400).
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Figure 2: Diffuse proliferation of malignant ltmphoid cells (hematoxylin and eosin, ×400).

Mentions: In February 2007, a 30-year-old woman presented to the gynecology clinic with a small painless mass at the urethral orifice. She underwent surgical excision of the lesion and histopathology revealed a mixture of acute and chronic inflammation consistent with urethral carbuncle. Two months later she presented with a hyperemic small swelling at the site of the excision. She underwent re-excision; and a mass from the urethral mucosa was biopsied. Pathologic examination of the specimen revealed a diffuse monotonous proliferation of malignant lymphoid cells of mostly large cell size; some of which are medium size and have a monocytoid appearance. The urethral mucosa above the infiltrate is focally infiltrated by malignant lymphoid cells (fig. 1, fig. 2). The deep component of the tumor infiltrates the glandular epithelium of the urethra (lymphoepithelial lesion); a feature strongly suggestive of MALT lymphoma (fig. 3). Immunohistochemistry for cytokeratin highlights these lesions (fig. 4, fig. 5). Immunocytochemistry studies demonstrated that the tumor cells have a strong positive reaction to CD45 (leukocytic common antigen, LCA) and CD20 (fig. 6).


Diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue lymphoma arising in a female urethra treated with rituximab for the first time.

Zahrani AA, Abdelsalam M, Fiaar AA, Ibrahim N, Al-Elawi A, Muhammad B - Case Rep Oncol (2012)

Diffuse proliferation of malignant ltmphoid cells (hematoxylin and eosin, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3369256&req=5

Figure 2: Diffuse proliferation of malignant ltmphoid cells (hematoxylin and eosin, ×400).
Mentions: In February 2007, a 30-year-old woman presented to the gynecology clinic with a small painless mass at the urethral orifice. She underwent surgical excision of the lesion and histopathology revealed a mixture of acute and chronic inflammation consistent with urethral carbuncle. Two months later she presented with a hyperemic small swelling at the site of the excision. She underwent re-excision; and a mass from the urethral mucosa was biopsied. Pathologic examination of the specimen revealed a diffuse monotonous proliferation of malignant lymphoid cells of mostly large cell size; some of which are medium size and have a monocytoid appearance. The urethral mucosa above the infiltrate is focally infiltrated by malignant lymphoid cells (fig. 1, fig. 2). The deep component of the tumor infiltrates the glandular epithelium of the urethra (lymphoepithelial lesion); a feature strongly suggestive of MALT lymphoma (fig. 3). Immunohistochemistry for cytokeratin highlights these lesions (fig. 4, fig. 5). Immunocytochemistry studies demonstrated that the tumor cells have a strong positive reaction to CD45 (leukocytic common antigen, LCA) and CD20 (fig. 6).

Bottom Line: Pathological examination revealed non-Hodgkin's lymphoma of diffuse large B-cell type and mucosa-associated lymphoid tissue type, stage IE.Patient follow-up was done 3 months later through CT scan and cytoscopy confirming the complete remission.The patient has been disease-free for 4 years.

View Article: PubMed Central - PubMed

Affiliation: Oncology Department, Riyadh Military Hospital, Riyadh, Kingdom of Saudi Arabia.

ABSTRACT
A 30-year-old female patient presented to the gynecology clinic with a small (painless) swelling at the urethral orifice. She underwent surgical excision of the lesion. Pathological examination revealed non-Hodgkin's lymphoma of diffuse large B-cell type and mucosa-associated lymphoid tissue type, stage IE. The patient refused radiotherapy. Accordingly, we started CHOP-R chemotherapy. She received a total of 6 cycles of CHOP and 8 cycles of rituximab. Patient follow-up was done 3 months later through CT scan and cytoscopy confirming the complete remission. The patient has been disease-free for 4 years. We reviewed 26 cases of this rare entity reported previously.

No MeSH data available.


Related in: MedlinePlus