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Remarkable regression of an osteolytic lesion of large cell lung cancer treated with zoledronic Acid: a case report.

Kawai S, Yamaura G, Yasuda K, Suzuki T - Case Rep Oncol (2012)

Bottom Line: Zoledronic acid suppresses osteoclastic changes and reduces the risk of cancer-induced skeletal-related events.Moreover, it has been reported to have antitumor effects.However, it was markedly regressed after zoledronic acid monotherapy, and the patient's symptoms almost disappeared.

View Article: PubMed Central - PubMed

Affiliation: Sendai Medical Center, Sendai, Japan.

ABSTRACT
Zoledronic acid suppresses osteoclastic changes and reduces the risk of cancer-induced skeletal-related events. Moreover, it has been reported to have antitumor effects. The authors here present a case of a male patient with large cell lung cancer who had an osteolytic lesion in the thoracic vertebrae. The cancer was moderately sensitive to radiation therapy but barely sensitive to chemotherapy with cytotoxic agents. However, it was markedly regressed after zoledronic acid monotherapy, and the patient's symptoms almost disappeared. This remarkable response of large cell lung cancer to zoledronic acid monotherapy is rare.

No MeSH data available.


Related in: MedlinePlus

Time course of the serum CEA tumor marker from January 2006 to October 2009. The green, blue, and yellow lines indicate the period of administration of carboplatin (CBDCA) + paclitaxel (PTX), gemcitabine (GEM), and zoledronic acid (ZOL), respectively.
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Figure 3: Time course of the serum CEA tumor marker from January 2006 to October 2009. The green, blue, and yellow lines indicate the period of administration of carboplatin (CBDCA) + paclitaxel (PTX), gemcitabine (GEM), and zoledronic acid (ZOL), respectively.

Mentions: In Japan, zoledronic acid was approved in January 2005 for hypercalcemia induced by malignant disease. In April 2006, it was also approved for bone metastasis of malignant disease. Zoledronic acid (4 mg per month) was administered to the patient from September 2006. In January 2007, after 5 administrations, his pain reduced drastically. Moreover, CEA was also reduced and marked regression of the vertebral and left apical lesions was observed (fig. 2, fig. 3). In March 2008, CT-guided biopsy revealed that the tumor was large cell lung cancer. Because the patient did not want to receive any cytotoxic chemotherapy, zoledronic acid monotherapy was continued until December 2008. No adverse events were observed. In February 2009, because of necrosis of the left upper and lower jaw, zoledronic acid was discontinued. In April 2009, due to aggravation of pain and dysesthesia of the lower limbs, the patient wished to undergo surgery involving the vertebrae despite the surgical risks. In the same month, laminectomy, posterior decompression and vertebral fusion were performed. Unfortunately, however, paralysis of the lower half of the body and bladder and rectal disturbance appeared postoperatively. Thereafter, the patient experienced pneumonia and a pressure ulcer, and he finally died in January 2010. Survival from the time of the appearance of symptoms was 5 years and 4 months.


Remarkable regression of an osteolytic lesion of large cell lung cancer treated with zoledronic Acid: a case report.

Kawai S, Yamaura G, Yasuda K, Suzuki T - Case Rep Oncol (2012)

Time course of the serum CEA tumor marker from January 2006 to October 2009. The green, blue, and yellow lines indicate the period of administration of carboplatin (CBDCA) + paclitaxel (PTX), gemcitabine (GEM), and zoledronic acid (ZOL), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3369252&req=5

Figure 3: Time course of the serum CEA tumor marker from January 2006 to October 2009. The green, blue, and yellow lines indicate the period of administration of carboplatin (CBDCA) + paclitaxel (PTX), gemcitabine (GEM), and zoledronic acid (ZOL), respectively.
Mentions: In Japan, zoledronic acid was approved in January 2005 for hypercalcemia induced by malignant disease. In April 2006, it was also approved for bone metastasis of malignant disease. Zoledronic acid (4 mg per month) was administered to the patient from September 2006. In January 2007, after 5 administrations, his pain reduced drastically. Moreover, CEA was also reduced and marked regression of the vertebral and left apical lesions was observed (fig. 2, fig. 3). In March 2008, CT-guided biopsy revealed that the tumor was large cell lung cancer. Because the patient did not want to receive any cytotoxic chemotherapy, zoledronic acid monotherapy was continued until December 2008. No adverse events were observed. In February 2009, because of necrosis of the left upper and lower jaw, zoledronic acid was discontinued. In April 2009, due to aggravation of pain and dysesthesia of the lower limbs, the patient wished to undergo surgery involving the vertebrae despite the surgical risks. In the same month, laminectomy, posterior decompression and vertebral fusion were performed. Unfortunately, however, paralysis of the lower half of the body and bladder and rectal disturbance appeared postoperatively. Thereafter, the patient experienced pneumonia and a pressure ulcer, and he finally died in January 2010. Survival from the time of the appearance of symptoms was 5 years and 4 months.

Bottom Line: Zoledronic acid suppresses osteoclastic changes and reduces the risk of cancer-induced skeletal-related events.Moreover, it has been reported to have antitumor effects.However, it was markedly regressed after zoledronic acid monotherapy, and the patient's symptoms almost disappeared.

View Article: PubMed Central - PubMed

Affiliation: Sendai Medical Center, Sendai, Japan.

ABSTRACT
Zoledronic acid suppresses osteoclastic changes and reduces the risk of cancer-induced skeletal-related events. Moreover, it has been reported to have antitumor effects. The authors here present a case of a male patient with large cell lung cancer who had an osteolytic lesion in the thoracic vertebrae. The cancer was moderately sensitive to radiation therapy but barely sensitive to chemotherapy with cytotoxic agents. However, it was markedly regressed after zoledronic acid monotherapy, and the patient's symptoms almost disappeared. This remarkable response of large cell lung cancer to zoledronic acid monotherapy is rare.

No MeSH data available.


Related in: MedlinePlus