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Complete Response of Isolated Para-aortic Lymph Node Recurrence from Rectosigmoid Cancer Treated by Chemoradiation Therapy with Capecitabine/Oxaliplatin plus Bevacizumab: A Case Report.

Miyazawa T, Ebe K, Koide N, Fujita N - Case Rep Oncol (2012)

Bottom Line: Abdominal computed tomography and positron emission tomography with 18-fluorodeoxyglucose did not reveal any para-aortic lymph node recurrence after chemoradiation therapy.Hence, this case was interpreted as a complete response.No recurrence was noted 6 months after the complete response.

View Article: PubMed Central - PubMed

Affiliation: Departments of Surgery and Joetsu General Hospital, Joetsu, Japan.

ABSTRACT
Para-aortic lymph node recurrence is a rare type of metastasis from colorectal cancer, and no treatment has yet been established. Here, we report on a case of isolated para-aortic lymph node metastasis from rectosigmoid cancer that showed complete response to chemoradiation therapy with capecitabine/oxaliplatin plus bevacizumab. A 58-year-old woman underwent high anterior resection for rectosigmoid cancer in 2009. Para-aortic lymph node recurrence occurred in 2011. She underwent radiation therapy (50 Gy) and 8 courses of capecitabine/oxaliplatin plus bevacizumab. Abdominal computed tomography and positron emission tomography with 18-fluorodeoxyglucose did not reveal any para-aortic lymph node recurrence after chemoradiation therapy. Hence, this case was interpreted as a complete response. No recurrence was noted 6 months after the complete response. Chemoradiation therapy with capecitabine/oxaliplatin plus bevacizumab is likely to be effective in treating patients with para-aortic lymph node recurrence.

No MeSH data available.


Related in: MedlinePlus

Imaging after chemoradiation therapy. Abdominal CT scan (a, b) and FDG-PET (c) did not reveal any PALR.
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Figure 2: Imaging after chemoradiation therapy. Abdominal CT scan (a, b) and FDG-PET (c) did not reveal any PALR.

Mentions: An abdominal CT scan and a FDG-PET/CT scan were performed after the radiation therapy and 8 cycles of XELOX plus bevacizumab and they did not reveal any PALR (fig. 2). Therefore, the case was considered to be a CR. As adjuvant therapy after radiation and XELOX plus bevacizumab, 8 cycles of capecitabine [900 mg/body, twice on days 1–14, every 3 weeks] were administered. No sign of recurrence or metastasis was noted 6 months after CR was confirmed.


Complete Response of Isolated Para-aortic Lymph Node Recurrence from Rectosigmoid Cancer Treated by Chemoradiation Therapy with Capecitabine/Oxaliplatin plus Bevacizumab: A Case Report.

Miyazawa T, Ebe K, Koide N, Fujita N - Case Rep Oncol (2012)

Imaging after chemoradiation therapy. Abdominal CT scan (a, b) and FDG-PET (c) did not reveal any PALR.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3369241&req=5

Figure 2: Imaging after chemoradiation therapy. Abdominal CT scan (a, b) and FDG-PET (c) did not reveal any PALR.
Mentions: An abdominal CT scan and a FDG-PET/CT scan were performed after the radiation therapy and 8 cycles of XELOX plus bevacizumab and they did not reveal any PALR (fig. 2). Therefore, the case was considered to be a CR. As adjuvant therapy after radiation and XELOX plus bevacizumab, 8 cycles of capecitabine [900 mg/body, twice on days 1–14, every 3 weeks] were administered. No sign of recurrence or metastasis was noted 6 months after CR was confirmed.

Bottom Line: Abdominal computed tomography and positron emission tomography with 18-fluorodeoxyglucose did not reveal any para-aortic lymph node recurrence after chemoradiation therapy.Hence, this case was interpreted as a complete response.No recurrence was noted 6 months after the complete response.

View Article: PubMed Central - PubMed

Affiliation: Departments of Surgery and Joetsu General Hospital, Joetsu, Japan.

ABSTRACT
Para-aortic lymph node recurrence is a rare type of metastasis from colorectal cancer, and no treatment has yet been established. Here, we report on a case of isolated para-aortic lymph node metastasis from rectosigmoid cancer that showed complete response to chemoradiation therapy with capecitabine/oxaliplatin plus bevacizumab. A 58-year-old woman underwent high anterior resection for rectosigmoid cancer in 2009. Para-aortic lymph node recurrence occurred in 2011. She underwent radiation therapy (50 Gy) and 8 courses of capecitabine/oxaliplatin plus bevacizumab. Abdominal computed tomography and positron emission tomography with 18-fluorodeoxyglucose did not reveal any para-aortic lymph node recurrence after chemoradiation therapy. Hence, this case was interpreted as a complete response. No recurrence was noted 6 months after the complete response. Chemoradiation therapy with capecitabine/oxaliplatin plus bevacizumab is likely to be effective in treating patients with para-aortic lymph node recurrence.

No MeSH data available.


Related in: MedlinePlus