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Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials.

Ghanizadeh A - Med Gas Res (2012)

Bottom Line: This study systematically reviews the current evidences for treating of autism with HBO therapy.The electronically search resulted in 18 title of publications.Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Psychiatry and Behavioral Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. ghanizad@sina.tums.ac.ir.

ABSTRACT
There is a controversy about the efficacy of hyperbaric oxygen (HBO) therapy for the treatment of autism. This study systematically reviews the current evidences for treating of autism with HBO therapy. According to PRISMA guidelines for a systematic review, the databases of MEDLINE/Pubmed, Google Scholar, and Randomised Controlled Trials in Hyperbaric Medicine were electronically searched. In addition, medical subject heading terms and text words for hyperbaric oxygen therapy and autism were used. The main inclusion criteria were published studies which reported the original data from the trials conducted on the patients with autism and assessed outcomes with a valid and reliable instrument. A quality assessment was also conducted. The electronically search resulted in 18 title of publications. Two studies were randomized, double-blind, controlled-clinical trials. While some uncontrolled and controlled studies suggested that HBO therapy is effective for the treatment of autism, these promising effects are not replicated. Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.

No MeSH data available.


Related in: MedlinePlus

Flowchart of PRISMA trial selection process.
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Related In: Results  -  Collection

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Figure 1: Flowchart of PRISMA trial selection process.

Mentions: Both the titles and the abstracts were evaluated for inclusion based on the participants, the design of trial, intervention, and outcomes assessment. The articles which did not meet the inclusion criteria were excluded from the study. A summary of the flow of information is displayed in Figure 1. The modified four-item Oxford scale, whose score ranges from 0 to 7, (cited by [19,20]) was used in order to assess the methodological validity of the articles (Table 1). Also the information about the specific diagnosis, HBO therapy and its duration and protocols, autism symptoms as outcome, and secondary outcomes (adverse effects) were collected.


Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials.

Ghanizadeh A - Med Gas Res (2012)

Flowchart of PRISMA trial selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369206&req=5

Figure 1: Flowchart of PRISMA trial selection process.
Mentions: Both the titles and the abstracts were evaluated for inclusion based on the participants, the design of trial, intervention, and outcomes assessment. The articles which did not meet the inclusion criteria were excluded from the study. A summary of the flow of information is displayed in Figure 1. The modified four-item Oxford scale, whose score ranges from 0 to 7, (cited by [19,20]) was used in order to assess the methodological validity of the articles (Table 1). Also the information about the specific diagnosis, HBO therapy and its duration and protocols, autism symptoms as outcome, and secondary outcomes (adverse effects) were collected.

Bottom Line: This study systematically reviews the current evidences for treating of autism with HBO therapy.The electronically search resulted in 18 title of publications.Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Research Center for Psychiatry and Behavioral Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. ghanizad@sina.tums.ac.ir.

ABSTRACT
There is a controversy about the efficacy of hyperbaric oxygen (HBO) therapy for the treatment of autism. This study systematically reviews the current evidences for treating of autism with HBO therapy. According to PRISMA guidelines for a systematic review, the databases of MEDLINE/Pubmed, Google Scholar, and Randomised Controlled Trials in Hyperbaric Medicine were electronically searched. In addition, medical subject heading terms and text words for hyperbaric oxygen therapy and autism were used. The main inclusion criteria were published studies which reported the original data from the trials conducted on the patients with autism and assessed outcomes with a valid and reliable instrument. A quality assessment was also conducted. The electronically search resulted in 18 title of publications. Two studies were randomized, double-blind, controlled-clinical trials. While some uncontrolled and controlled studies suggested that HBO therapy is effective for the treatment of autism, these promising effects are not replicated. Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.

No MeSH data available.


Related in: MedlinePlus