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Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report.

Qiao T, Ma RH, Luo XB, Feng YY, Wang XQ, Zheng PM, Luo ZL - Eur. J. Med. Res. (2012)

Bottom Line: Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder.In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of cystine gallstones in humans.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Gallbladder Disease of Panyu, Guangzhou 511470, People's Republic of China. fqj1958@163.com

ABSTRACT
Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder. In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of cystine gallstones in humans.

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Related in: MedlinePlus

Results of analysis with spectrogram and electron microscope. (A,B) FTIR spectrogram of (A) small stones, showing that the main component was cystine, and (B) of the large stones, showing that the main component was cholesterol. (C-R) Scanning electron microscopy of the small cystine and large cholesterol stones. The small cystine stones displayed (C,D) hexagon crystals of unequal size, some with prominences on the edge (original magnification ×400) and (G,H,K,L) hexagon crystals stacked and arranged tightly. Original magnification (G,H) ×1,000; (K,L) ×3,000. (O,P) A view of one corner of a hexagon crystal shows that the end of the prominence is lamellar (original magnification ×6,000). The large cholesterol stones showed (E,F) amellar cholesterol crystals (original magnification ×400) and (I,J,M,N) stacked lamellar cholesterol crystals, Original magnification (I,J) ×1,000; (M,N) ×3,000. (Q,R) The cholesterol crystals had a smooth, glossy surface, dull borders, and a pyknomorphous texture (original magnification×6,000). (S) X-ray energy spectrogram Sa, spectrogram of the small stones (the elemental composition was carbon, oxygen, nitrogen, and sulfur) Sb, spectrogram of the large stones (the elemental composition was carbon and oxygen).
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Figure 3: Results of analysis with spectrogram and electron microscope. (A,B) FTIR spectrogram of (A) small stones, showing that the main component was cystine, and (B) of the large stones, showing that the main component was cholesterol. (C-R) Scanning electron microscopy of the small cystine and large cholesterol stones. The small cystine stones displayed (C,D) hexagon crystals of unequal size, some with prominences on the edge (original magnification ×400) and (G,H,K,L) hexagon crystals stacked and arranged tightly. Original magnification (G,H) ×1,000; (K,L) ×3,000. (O,P) A view of one corner of a hexagon crystal shows that the end of the prominence is lamellar (original magnification ×6,000). The large cholesterol stones showed (E,F) amellar cholesterol crystals (original magnification ×400) and (I,J,M,N) stacked lamellar cholesterol crystals, Original magnification (I,J) ×1,000; (M,N) ×3,000. (Q,R) The cholesterol crystals had a smooth, glossy surface, dull borders, and a pyknomorphous texture (original magnification×6,000). (S) X-ray energy spectrogram Sa, spectrogram of the small stones (the elemental composition was carbon, oxygen, nitrogen, and sulfur) Sb, spectrogram of the large stones (the elemental composition was carbon and oxygen).

Mentions: The gallbladder stones were analyzed with a Fourier transform infrared spectrometer (TENSOR27; Bruker Optics GmBH, Ettlingen, Germany) in the frequency range of 400 to 4,000 per cm at 4 per cm resolution. The results indicated that the small stones were cystine stones and that the large stones were cholesterol stones; (Figure 3A, B).


Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report.

Qiao T, Ma RH, Luo XB, Feng YY, Wang XQ, Zheng PM, Luo ZL - Eur. J. Med. Res. (2012)

Results of analysis with spectrogram and electron microscope. (A,B) FTIR spectrogram of (A) small stones, showing that the main component was cystine, and (B) of the large stones, showing that the main component was cholesterol. (C-R) Scanning electron microscopy of the small cystine and large cholesterol stones. The small cystine stones displayed (C,D) hexagon crystals of unequal size, some with prominences on the edge (original magnification ×400) and (G,H,K,L) hexagon crystals stacked and arranged tightly. Original magnification (G,H) ×1,000; (K,L) ×3,000. (O,P) A view of one corner of a hexagon crystal shows that the end of the prominence is lamellar (original magnification ×6,000). The large cholesterol stones showed (E,F) amellar cholesterol crystals (original magnification ×400) and (I,J,M,N) stacked lamellar cholesterol crystals, Original magnification (I,J) ×1,000; (M,N) ×3,000. (Q,R) The cholesterol crystals had a smooth, glossy surface, dull borders, and a pyknomorphous texture (original magnification×6,000). (S) X-ray energy spectrogram Sa, spectrogram of the small stones (the elemental composition was carbon, oxygen, nitrogen, and sulfur) Sb, spectrogram of the large stones (the elemental composition was carbon and oxygen).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3369205&req=5

Figure 3: Results of analysis with spectrogram and electron microscope. (A,B) FTIR spectrogram of (A) small stones, showing that the main component was cystine, and (B) of the large stones, showing that the main component was cholesterol. (C-R) Scanning electron microscopy of the small cystine and large cholesterol stones. The small cystine stones displayed (C,D) hexagon crystals of unequal size, some with prominences on the edge (original magnification ×400) and (G,H,K,L) hexagon crystals stacked and arranged tightly. Original magnification (G,H) ×1,000; (K,L) ×3,000. (O,P) A view of one corner of a hexagon crystal shows that the end of the prominence is lamellar (original magnification ×6,000). The large cholesterol stones showed (E,F) amellar cholesterol crystals (original magnification ×400) and (I,J,M,N) stacked lamellar cholesterol crystals, Original magnification (I,J) ×1,000; (M,N) ×3,000. (Q,R) The cholesterol crystals had a smooth, glossy surface, dull borders, and a pyknomorphous texture (original magnification×6,000). (S) X-ray energy spectrogram Sa, spectrogram of the small stones (the elemental composition was carbon, oxygen, nitrogen, and sulfur) Sb, spectrogram of the large stones (the elemental composition was carbon and oxygen).
Mentions: The gallbladder stones were analyzed with a Fourier transform infrared spectrometer (TENSOR27; Bruker Optics GmBH, Ettlingen, Germany) in the frequency range of 400 to 4,000 per cm at 4 per cm resolution. The results indicated that the small stones were cystine stones and that the large stones were cholesterol stones; (Figure 3A, B).

Bottom Line: Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder.In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of cystine gallstones in humans.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Gallbladder Disease of Panyu, Guangzhou 511470, People's Republic of China. fqj1958@163.com

ABSTRACT
Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder. In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of cystine gallstones in humans.

Show MeSH
Related in: MedlinePlus