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IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease.

Qi HP, Qu ZY, Duan SR, Wei SQ, Wen SR, Bi S - PLoS ONE (2012)

Bottom Line: For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs.As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs.In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

ABSTRACT
Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52-0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR= 0.73, 95% CI = 0.62-0.86) and in additive model (GG vs. CC, OR= 0.66, 95% CI = 0.46-0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

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Related in: MedlinePlus

Forest plot of AD risk associated with IL-6-572 C/G polymorphism at dominant model (CG+GG genotype vs. CC genotype).The squares and horizontal lines correspond to the study-specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI.
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pone-0037858-g004: Forest plot of AD risk associated with IL-6-572 C/G polymorphism at dominant model (CG+GG genotype vs. CC genotype).The squares and horizontal lines correspond to the study-specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI.

Mentions: The genotype frequency of the IL-6 polymorphisms between case and control groups were presented in Table 2 and 3. For IL-6-174 G/C polymorphism, the combined results based on all studies showed the evidence of an association between the decreased risk of AD and the variant genotypes in recessive model (CC vs. CG+GG: OR  = 0.65, 95% CI = 0.52–0.82, P = 0.0003, Figure 2). There was significant heterogeneity (I2 = 65%). No associations were found in dominant model or additive model. For IL-6-572 C/G polymorphism, significant decreased risk was found in additive model (GG vs. CC: OR  = 0.66, 95% CI = 0.46–0.96, Figure 3) and dominant model (CG+GG vs. CC: OR  = 0.73, 95% CI = 0.62–0.86, Figure 4). No heterogeneity was found. No associations were found in recessive model.


IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease.

Qi HP, Qu ZY, Duan SR, Wei SQ, Wen SR, Bi S - PLoS ONE (2012)

Forest plot of AD risk associated with IL-6-572 C/G polymorphism at dominant model (CG+GG genotype vs. CC genotype).The squares and horizontal lines correspond to the study-specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368923&req=5

pone-0037858-g004: Forest plot of AD risk associated with IL-6-572 C/G polymorphism at dominant model (CG+GG genotype vs. CC genotype).The squares and horizontal lines correspond to the study-specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI.
Mentions: The genotype frequency of the IL-6 polymorphisms between case and control groups were presented in Table 2 and 3. For IL-6-174 G/C polymorphism, the combined results based on all studies showed the evidence of an association between the decreased risk of AD and the variant genotypes in recessive model (CC vs. CG+GG: OR  = 0.65, 95% CI = 0.52–0.82, P = 0.0003, Figure 2). There was significant heterogeneity (I2 = 65%). No associations were found in dominant model or additive model. For IL-6-572 C/G polymorphism, significant decreased risk was found in additive model (GG vs. CC: OR  = 0.66, 95% CI = 0.46–0.96, Figure 3) and dominant model (CG+GG vs. CC: OR  = 0.73, 95% CI = 0.62–0.86, Figure 4). No heterogeneity was found. No associations were found in recessive model.

Bottom Line: For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs.As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs.In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

ABSTRACT
Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52-0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR= 0.73, 95% CI = 0.62-0.86) and in additive model (GG vs. CC, OR= 0.66, 95% CI = 0.46-0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

Show MeSH
Related in: MedlinePlus