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IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease.

Qi HP, Qu ZY, Duan SR, Wei SQ, Wen SR, Bi S - PLoS ONE (2012)

Bottom Line: For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs.As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs.In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

ABSTRACT
Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52-0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR= 0.73, 95% CI = 0.62-0.86) and in additive model (GG vs. CC, OR= 0.66, 95% CI = 0.46-0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

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Related in: MedlinePlus

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pone-0037858-g001: PRISMA Flow Diagram.

Mentions: In this article, the associations of IL-6 polymorphisms with AD susceptibility were investigated using meta-analysis in a wide range of populations (Figure 1). Twenty-seven case-control studies (22 studies on IL-6-174 G/C polymorphism[15]–[36] and 5 studies on IL-6-572 C/G studies polymorphism[8]–[12]) met all of the inclusion criteria and were included in the review. The detailed characteristics of these studies are presented in Table 1. No evidence of publication biases were observed in Funnel plots (available upon request). Totally 4,280 AD patients and 8,788 controls for IL-6-174 G/C polymorphism and 2,352 AD patients and 3,715 controls for IL-6-572 C/G polymorphism were included in the analyses. Among included studies, five studies[12], [15]–[18] only reported GG and GC genotypes vs. CC genotype and one [19] only reported GC and CC genotypes vs. GG genotype information in their paper. Among the included studies, 17 studies were on IL-6-174 G/C allele contrast and additive model, 19 studies were on IL-6-174 G/C dominant genetic model and 20 studies were on IL-6-174 G/C recessive model. Though the number of studies on IL-6-572 C/G polymorphism was small, they were also included for a comprehensive evaluation in this study.


IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease.

Qi HP, Qu ZY, Duan SR, Wei SQ, Wen SR, Bi S - PLoS ONE (2012)

PRISMA Flow Diagram.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368923&req=5

pone-0037858-g001: PRISMA Flow Diagram.
Mentions: In this article, the associations of IL-6 polymorphisms with AD susceptibility were investigated using meta-analysis in a wide range of populations (Figure 1). Twenty-seven case-control studies (22 studies on IL-6-174 G/C polymorphism[15]–[36] and 5 studies on IL-6-572 C/G studies polymorphism[8]–[12]) met all of the inclusion criteria and were included in the review. The detailed characteristics of these studies are presented in Table 1. No evidence of publication biases were observed in Funnel plots (available upon request). Totally 4,280 AD patients and 8,788 controls for IL-6-174 G/C polymorphism and 2,352 AD patients and 3,715 controls for IL-6-572 C/G polymorphism were included in the analyses. Among included studies, five studies[12], [15]–[18] only reported GG and GC genotypes vs. CC genotype and one [19] only reported GC and CC genotypes vs. GG genotype information in their paper. Among the included studies, 17 studies were on IL-6-174 G/C allele contrast and additive model, 19 studies were on IL-6-174 G/C dominant genetic model and 20 studies were on IL-6-174 G/C recessive model. Though the number of studies on IL-6-572 C/G polymorphism was small, they were also included for a comprehensive evaluation in this study.

Bottom Line: For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs.As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs.In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

ABSTRACT
Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52-0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR= 0.73, 95% CI = 0.62-0.86) and in additive model (GG vs. CC, OR= 0.66, 95% CI = 0.46-0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

Show MeSH
Related in: MedlinePlus