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Role of matrix metaloproteases in idiopathic pulmonary fibrosis.

Pardo A, Selman M - Fibrogenesis Tissue Repair (2012)

Bottom Line: The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by alveolar epithelial cell injury/activation, expansion of the fibroblast/myofibroblast population, and the exaggerated accumulation of extracellular matrix [ECM] components which ultimately result in the destruction of the lung parenchyma.Several matrix metalloproteases [MMPs] are upregulated in the IPF lungs and have been shown to actively participate in the pathogenesis of the disease through extracellular matrix remodeling and basement membrane disruption.However, MMPs can also breakdown molecules that mediate cell-cell and cell-ECM interactions, and can activate growth factors and growth factor receptors indicating that they likely contribute to other local biopathological processes such as apoptosis, migration, proliferation and angiogenesis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, CP 04510, México DF, México ; Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Tlalpan 4502, CP 14080, México DF, México.

ABSTRACT
Lung fibrosis is the final common pathway of a large variety of chronic lung disorders, named interstitial lung diseases. The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by alveolar epithelial cell injury/activation, expansion of the fibroblast/myofibroblast population, and the exaggerated accumulation of extracellular matrix [ECM] components which ultimately result in the destruction of the lung parenchyma. Several matrix metalloproteases [MMPs] are upregulated in the IPF lungs and have been shown to actively participate in the pathogenesis of the disease through extracellular matrix remodeling and basement membrane disruption. However, MMPs can also breakdown molecules that mediate cell-cell and cell-ECM interactions, and can activate growth factors and growth factor receptors indicating that they likely contribute to other local biopathological processes such as apoptosis, migration, proliferation and angiogenesis.

No MeSH data available.


Related in: MedlinePlus

MMPs and TIMPs expression levels by microarray analysis from controls and IPF lungs. Increased genes are shown in progressively brighter shades of yellow, and decreased genes are shown in progressively darker shades of blue. Genes shown in gray are not different between the groups.
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Figure 1: MMPs and TIMPs expression levels by microarray analysis from controls and IPF lungs. Increased genes are shown in progressively brighter shades of yellow, and decreased genes are shown in progressively darker shades of blue. Genes shown in gray are not different between the groups.

Mentions: The transcriptional signature and immunohistochemical analyses of IPF lungs have revealed that several MMPs, primarily MMP1 and MMP7 are among the molecules that are more significantly overexpressed compared with control lungs [16,23] (Figure 1).


Role of matrix metaloproteases in idiopathic pulmonary fibrosis.

Pardo A, Selman M - Fibrogenesis Tissue Repair (2012)

MMPs and TIMPs expression levels by microarray analysis from controls and IPF lungs. Increased genes are shown in progressively brighter shades of yellow, and decreased genes are shown in progressively darker shades of blue. Genes shown in gray are not different between the groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368759&req=5

Figure 1: MMPs and TIMPs expression levels by microarray analysis from controls and IPF lungs. Increased genes are shown in progressively brighter shades of yellow, and decreased genes are shown in progressively darker shades of blue. Genes shown in gray are not different between the groups.
Mentions: The transcriptional signature and immunohistochemical analyses of IPF lungs have revealed that several MMPs, primarily MMP1 and MMP7 are among the molecules that are more significantly overexpressed compared with control lungs [16,23] (Figure 1).

Bottom Line: The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by alveolar epithelial cell injury/activation, expansion of the fibroblast/myofibroblast population, and the exaggerated accumulation of extracellular matrix [ECM] components which ultimately result in the destruction of the lung parenchyma.Several matrix metalloproteases [MMPs] are upregulated in the IPF lungs and have been shown to actively participate in the pathogenesis of the disease through extracellular matrix remodeling and basement membrane disruption.However, MMPs can also breakdown molecules that mediate cell-cell and cell-ECM interactions, and can activate growth factors and growth factor receptors indicating that they likely contribute to other local biopathological processes such as apoptosis, migration, proliferation and angiogenesis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, CP 04510, México DF, México ; Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Tlalpan 4502, CP 14080, México DF, México.

ABSTRACT
Lung fibrosis is the final common pathway of a large variety of chronic lung disorders, named interstitial lung diseases. The most aggressive form is the idiopathic pulmonary fibrosis [IPF] characterized by alveolar epithelial cell injury/activation, expansion of the fibroblast/myofibroblast population, and the exaggerated accumulation of extracellular matrix [ECM] components which ultimately result in the destruction of the lung parenchyma. Several matrix metalloproteases [MMPs] are upregulated in the IPF lungs and have been shown to actively participate in the pathogenesis of the disease through extracellular matrix remodeling and basement membrane disruption. However, MMPs can also breakdown molecules that mediate cell-cell and cell-ECM interactions, and can activate growth factors and growth factor receptors indicating that they likely contribute to other local biopathological processes such as apoptosis, migration, proliferation and angiogenesis.

No MeSH data available.


Related in: MedlinePlus