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Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.

Jiang S, Fang Q, Yu W, Zhang R, Hu C, Dong K, Bao Y, Wang C, Xiang K, Jia W - BMC Med. Genet. (2012)

Bottom Line: Moreover, we investigated the effects of these SNPs on obesity-related quantitative traits in all participants. rs2272495 was associated with BMI (p = 0.015), waist circumference (p = 0.006), hip circumference (p = 0.025) as well as WHR (p = 0.047) under a recessive model.Similar associations were found for rs1107756 except for WHR.This study suggests that genetic variations in APPL2 are associated with overweight and obesity in Chinese population with normal glucose tolerance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

ABSTRACT

Background: APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of adiponectin receptors in muscle cells. Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. However, the association between genetic variations of APPL2 and metabolic traits remains unknown. In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance.

Methods: We genotyped six single nucleotide polymorphisms (SNPs) in APPL2 in 1,808 non-diabetic subjects. Overweight and obesity were defined by body mass index (BMI). Obesity-related anthropometric parameters were measured, including height, weight, waist circumference, hip circumference. BMI and waist-hip ratio (WHR) were calculated.

Results: We found significant evidence of association with overweight/obesity for rs2272495 and rs1107756. rs2272495 C allele and rs1107756 T allele both conferred a higher risk of being overweight and obese (OR 1.218, 95% CI 1.047-1.416, p = 0.011 for rs2272495; OR 1.166, 95% CI 1.014-1.341, p = 0.031 for rs1107756). After adjusting multiple comparisons, only the effect of rs2272495 on overweight/obesity remained to be significant (empirical p = 0.043). Moreover, we investigated the effects of these SNPs on obesity-related quantitative traits in all participants. rs2272495 was associated with BMI (p = 0.015), waist circumference (p = 0.006), hip circumference (p = 0.025) as well as WHR (p = 0.047) under a recessive model. Similar associations were found for rs1107756 except for WHR.

Conclusion: This study suggests that genetic variations in APPL2 are associated with overweight and obesity in Chinese population with normal glucose tolerance.

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Linkage disequilibrium maps for SNPs genotyped in APPL2 in the Chinese subjects with normal glucose tolerance. A Shades of red demonstrate the strength of the pairwise linkage disequilibrium based on /D'/ and numbers indicate the value of /D'/ expressed as a percentage. B Shades of grey demonstrate the strength of pairwise linkage disequilibrium based on r2, and numbers indicate the value of r2 expressed as a percentage.
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Figure 1: Linkage disequilibrium maps for SNPs genotyped in APPL2 in the Chinese subjects with normal glucose tolerance. A Shades of red demonstrate the strength of the pairwise linkage disequilibrium based on /D'/ and numbers indicate the value of /D'/ expressed as a percentage. B Shades of grey demonstrate the strength of pairwise linkage disequilibrium based on r2, and numbers indicate the value of r2 expressed as a percentage.

Mentions: Linkage disequilibrium analysis revealed that these five SNPs were in modest linkage disequilibrium and formed two haplotype blocks in this region (Figure 1).


Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance.

Jiang S, Fang Q, Yu W, Zhang R, Hu C, Dong K, Bao Y, Wang C, Xiang K, Jia W - BMC Med. Genet. (2012)

Linkage disequilibrium maps for SNPs genotyped in APPL2 in the Chinese subjects with normal glucose tolerance. A Shades of red demonstrate the strength of the pairwise linkage disequilibrium based on /D'/ and numbers indicate the value of /D'/ expressed as a percentage. B Shades of grey demonstrate the strength of pairwise linkage disequilibrium based on r2, and numbers indicate the value of r2 expressed as a percentage.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368742&req=5

Figure 1: Linkage disequilibrium maps for SNPs genotyped in APPL2 in the Chinese subjects with normal glucose tolerance. A Shades of red demonstrate the strength of the pairwise linkage disequilibrium based on /D'/ and numbers indicate the value of /D'/ expressed as a percentage. B Shades of grey demonstrate the strength of pairwise linkage disequilibrium based on r2, and numbers indicate the value of r2 expressed as a percentage.
Mentions: Linkage disequilibrium analysis revealed that these five SNPs were in modest linkage disequilibrium and formed two haplotype blocks in this region (Figure 1).

Bottom Line: Moreover, we investigated the effects of these SNPs on obesity-related quantitative traits in all participants. rs2272495 was associated with BMI (p = 0.015), waist circumference (p = 0.006), hip circumference (p = 0.025) as well as WHR (p = 0.047) under a recessive model.Similar associations were found for rs1107756 except for WHR.This study suggests that genetic variations in APPL2 are associated with overweight and obesity in Chinese population with normal glucose tolerance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

ABSTRACT

Background: APPL1 and APPL2 are two adaptor proteins, which can mediate adiponectin signaling via binding to N terminus of adiponectin receptors in muscle cells. Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. However, the association between genetic variations of APPL2 and metabolic traits remains unknown. In the current study, we aimed to test the impacts of APPL2 genetic variants on obesity in a Chinese population with normal glucose tolerance.

Methods: We genotyped six single nucleotide polymorphisms (SNPs) in APPL2 in 1,808 non-diabetic subjects. Overweight and obesity were defined by body mass index (BMI). Obesity-related anthropometric parameters were measured, including height, weight, waist circumference, hip circumference. BMI and waist-hip ratio (WHR) were calculated.

Results: We found significant evidence of association with overweight/obesity for rs2272495 and rs1107756. rs2272495 C allele and rs1107756 T allele both conferred a higher risk of being overweight and obese (OR 1.218, 95% CI 1.047-1.416, p = 0.011 for rs2272495; OR 1.166, 95% CI 1.014-1.341, p = 0.031 for rs1107756). After adjusting multiple comparisons, only the effect of rs2272495 on overweight/obesity remained to be significant (empirical p = 0.043). Moreover, we investigated the effects of these SNPs on obesity-related quantitative traits in all participants. rs2272495 was associated with BMI (p = 0.015), waist circumference (p = 0.006), hip circumference (p = 0.025) as well as WHR (p = 0.047) under a recessive model. Similar associations were found for rs1107756 except for WHR.

Conclusion: This study suggests that genetic variations in APPL2 are associated with overweight and obesity in Chinese population with normal glucose tolerance.

Show MeSH
Related in: MedlinePlus