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NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions.

Kim DE, Noh SM, Jeong SW, Cha MH - BMC Res Notes (2012)

Bottom Line: In the quantitative MR lesion maps from age-sex matched subgroups (n = 124 or 126), there was no difference between the patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype.Unexpectedly, the extent of leukoaraiosis on FLAIR-MR images tended to be smaller in the corona radiata and centrum semiovale of the patients with the rs12425791 A/A or G/A genotype than in those with the G/G genotype (P = 0.052).Further studies are required to confirm our preliminary findings.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea. kdongeog@duih.org

ABSTRACT

Background: To investigate if single nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 would be associated with earlier-onset (vs. late-onset) first-ever ischemic stroke and increase silent cerebrovascular lesions prior to the manifestation of the stroke.

Methods: We prospectively enrolled 164 patients (67.6 ± 12.9 years, 92 men) admitted with first-ever ischemic strokes. All patients underwent genotyping of rs11833579 and rs12425791 as well as systemic investigations including magnetic resonance (MR) imaging and other vascular workup. Stroke-related MR lesions were registered on a brain-template-set using a custom-built software package 'Image_QNA': high-signal-intensity ischemic lesions on diffusion, T2-weighted, or fluid attenuation inversion recovery (FLAIR) MR images, and low signal intensity hemorrhagic lesions on gradient-echo MR images.

Results: The rs11833579 A/A or G/A genotype was independently associated with the first-ever ischemic stroke before the age 59 vs. 59 or over, after adjusting for cardiovascular risk factors and prior medication of antiplatelet or anticoagulant drugs, increasing the risk by about 2.5 fold. In the quantitative MR lesion maps from age-sex matched subgroups (n = 124 or 126), there was no difference between the patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype. Unexpectedly, the extent of leukoaraiosis on FLAIR-MR images tended to be smaller in the corona radiata and centrum semiovale of the patients with the rs12425791 A/A or G/A genotype than in those with the G/G genotype (P = 0.052). Neither the rs11833579 nor the rs12425791 genotype significantly affected initial stroke severity; however the latter was associated with relatively low modified Rankin scale scores at 1 year after stroke.

Conclusions: The rs11833579 A/A or G/A genotype may bring forward the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions prior to the stroke. Further studies are required to confirm our preliminary findings.

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Related in: MedlinePlus

Accumulation MR lesion maps depending on the rs11833579 (A) or rs12425791 (B) genotype. Quantitative maps of diffusion/fluid attenuation inversion recovery (FLAIR)/T2/gradient-echo (GE) MR images show no significant difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (A). In the age-sex matched patients with the rs12425791 A/A or G/A genotype (B), compared with the ones with the G/G genotype, the extent of leukoaraiosis in the centrum semiovale (first row) and corona radiata (second row) on FLAIR MRIs appears to be smaller. The pseudocolor bars indicate numbers of subjects with lesions overlapping a specific pixel.
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Figure 2: Accumulation MR lesion maps depending on the rs11833579 (A) or rs12425791 (B) genotype. Quantitative maps of diffusion/fluid attenuation inversion recovery (FLAIR)/T2/gradient-echo (GE) MR images show no significant difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (A). In the age-sex matched patients with the rs12425791 A/A or G/A genotype (B), compared with the ones with the G/G genotype, the extent of leukoaraiosis in the centrum semiovale (first row) and corona radiata (second row) on FLAIR MRIs appears to be smaller. The pseudocolor bars indicate numbers of subjects with lesions overlapping a specific pixel.

Mentions: In the quantitative mapping of stroke-related lesions on diffusion/FLAIR/T2/GE MR images, there was no difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (Figure 2A). Likewise, there was no difference in the MR images of the age-sex matched patients with the rs12425791 A/A or G/A genotype vs. those with the G/G genotype, except that the extent of leukoaraiosis in the corona radiata and centrum semiovale tended to be smaller in the former (1861 ± 2437 pixels) than in the latter (1136 ± 1528 pixels, P = 0.052) (Figure 2B).


NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions.

Kim DE, Noh SM, Jeong SW, Cha MH - BMC Res Notes (2012)

Accumulation MR lesion maps depending on the rs11833579 (A) or rs12425791 (B) genotype. Quantitative maps of diffusion/fluid attenuation inversion recovery (FLAIR)/T2/gradient-echo (GE) MR images show no significant difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (A). In the age-sex matched patients with the rs12425791 A/A or G/A genotype (B), compared with the ones with the G/G genotype, the extent of leukoaraiosis in the centrum semiovale (first row) and corona radiata (second row) on FLAIR MRIs appears to be smaller. The pseudocolor bars indicate numbers of subjects with lesions overlapping a specific pixel.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368733&req=5

Figure 2: Accumulation MR lesion maps depending on the rs11833579 (A) or rs12425791 (B) genotype. Quantitative maps of diffusion/fluid attenuation inversion recovery (FLAIR)/T2/gradient-echo (GE) MR images show no significant difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (A). In the age-sex matched patients with the rs12425791 A/A or G/A genotype (B), compared with the ones with the G/G genotype, the extent of leukoaraiosis in the centrum semiovale (first row) and corona radiata (second row) on FLAIR MRIs appears to be smaller. The pseudocolor bars indicate numbers of subjects with lesions overlapping a specific pixel.
Mentions: In the quantitative mapping of stroke-related lesions on diffusion/FLAIR/T2/GE MR images, there was no difference between the age-sex matched patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype (Figure 2A). Likewise, there was no difference in the MR images of the age-sex matched patients with the rs12425791 A/A or G/A genotype vs. those with the G/G genotype, except that the extent of leukoaraiosis in the corona radiata and centrum semiovale tended to be smaller in the former (1861 ± 2437 pixels) than in the latter (1136 ± 1528 pixels, P = 0.052) (Figure 2B).

Bottom Line: In the quantitative MR lesion maps from age-sex matched subgroups (n = 124 or 126), there was no difference between the patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype.Unexpectedly, the extent of leukoaraiosis on FLAIR-MR images tended to be smaller in the corona radiata and centrum semiovale of the patients with the rs12425791 A/A or G/A genotype than in those with the G/G genotype (P = 0.052).Further studies are required to confirm our preliminary findings.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea. kdongeog@duih.org

ABSTRACT

Background: To investigate if single nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 would be associated with earlier-onset (vs. late-onset) first-ever ischemic stroke and increase silent cerebrovascular lesions prior to the manifestation of the stroke.

Methods: We prospectively enrolled 164 patients (67.6 ± 12.9 years, 92 men) admitted with first-ever ischemic strokes. All patients underwent genotyping of rs11833579 and rs12425791 as well as systemic investigations including magnetic resonance (MR) imaging and other vascular workup. Stroke-related MR lesions were registered on a brain-template-set using a custom-built software package 'Image_QNA': high-signal-intensity ischemic lesions on diffusion, T2-weighted, or fluid attenuation inversion recovery (FLAIR) MR images, and low signal intensity hemorrhagic lesions on gradient-echo MR images.

Results: The rs11833579 A/A or G/A genotype was independently associated with the first-ever ischemic stroke before the age 59 vs. 59 or over, after adjusting for cardiovascular risk factors and prior medication of antiplatelet or anticoagulant drugs, increasing the risk by about 2.5 fold. In the quantitative MR lesion maps from age-sex matched subgroups (n = 124 or 126), there was no difference between the patients with the rs11833579 A/A or G/A genotype and those with the G/G genotype. Unexpectedly, the extent of leukoaraiosis on FLAIR-MR images tended to be smaller in the corona radiata and centrum semiovale of the patients with the rs12425791 A/A or G/A genotype than in those with the G/G genotype (P = 0.052). Neither the rs11833579 nor the rs12425791 genotype significantly affected initial stroke severity; however the latter was associated with relatively low modified Rankin scale scores at 1 year after stroke.

Conclusions: The rs11833579 A/A or G/A genotype may bring forward the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions prior to the stroke. Further studies are required to confirm our preliminary findings.

Show MeSH
Related in: MedlinePlus