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Influence of change in aerobic fitness and weight on prevalence of metabolic syndrome.

Crist LA, Champagne CM, Corsino L, Lien LF, Zhang G, Young DR - Prev Chronic Dis (2012)

Bottom Line: When combining intervention and control groups, at 6 and 18 months, a 1-beat-per-minute reduction in heart rate was associated with a 4% reduction in prevalence of metabolic syndrome (P < .001).When we tested for weight change as a mediator, the association was no longer significant.This association appears to be mediated through concomitant weight change.

View Article: PubMed Central - PubMed

Affiliation: University of Maryland School of Public Health, College Park, Maryland, USA.

ABSTRACT

Introduction: The metabolic syndrome is the clustering of several cardiometabolic risk factors that can lead to the development of coronary heart disease and type 2 diabetes. We evaluated whether a change in aerobic fitness resulting from a lifestyle intervention could significantly change the odds of metabolic syndrome prevalence.

Methods: Participants (n = 810) were recruited into PREMIER, a multicenter, randomized, controlled clinical trial with outcome assessments at 6 and 18 months. The primary eligibility criterion was a diagnosis of prehypertension or stage 1 hypertension. PREMIER randomized participants to 2 lifestyle interventions, both of which included increased physical activity, or an advice-only control group. Participants completed a submaximal treadmill exercise test; we used reduction in heart rate as the measure of improved aerobic fitness. We used logistic regression to determine intervention effects on metabolic syndrome prevalence. Our models controlled for dietary pattern change.

Results: The lifestyle interventions had no significant effect on metabolic syndrome prevalence at 6 months or 18 months. When combining intervention and control groups, at 6 and 18 months, a 1-beat-per-minute reduction in heart rate was associated with a 4% reduction in prevalence of metabolic syndrome (P < .001). When we tested for weight change as a mediator, the association was no longer significant.

Conclusion: Increased aerobic fitness may reduce prevalence of metabolic syndrome. This association appears to be mediated through concomitant weight change.

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Related in: MedlinePlus

Prevalence of metabolic syndrome, by treatment status, at baseline and 6- and 18-month follow-up among participants in the PREMIER trial, Louisiana, Maryland, Oregon, North Carolina, 1998-2004.
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Figure 1: Prevalence of metabolic syndrome, by treatment status, at baseline and 6- and 18-month follow-up among participants in the PREMIER trial, Louisiana, Maryland, Oregon, North Carolina, 1998-2004.

Mentions: Prevalence of metabolic syndrome decreased to 34% at 6 months and 32% at 18 months in the control group and to 31% at 6 months and 33% at 18 months in the combined lifestyle treatment (CLT) group (Figure). Lower fitness was significantly associated with higher prevalence of metabolic syndrome at baseline, 6, and 18 months.


Influence of change in aerobic fitness and weight on prevalence of metabolic syndrome.

Crist LA, Champagne CM, Corsino L, Lien LF, Zhang G, Young DR - Prev Chronic Dis (2012)

Prevalence of metabolic syndrome, by treatment status, at baseline and 6- and 18-month follow-up among participants in the PREMIER trial, Louisiana, Maryland, Oregon, North Carolina, 1998-2004.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368700&req=5

Figure 1: Prevalence of metabolic syndrome, by treatment status, at baseline and 6- and 18-month follow-up among participants in the PREMIER trial, Louisiana, Maryland, Oregon, North Carolina, 1998-2004.
Mentions: Prevalence of metabolic syndrome decreased to 34% at 6 months and 32% at 18 months in the control group and to 31% at 6 months and 33% at 18 months in the combined lifestyle treatment (CLT) group (Figure). Lower fitness was significantly associated with higher prevalence of metabolic syndrome at baseline, 6, and 18 months.

Bottom Line: When combining intervention and control groups, at 6 and 18 months, a 1-beat-per-minute reduction in heart rate was associated with a 4% reduction in prevalence of metabolic syndrome (P < .001).When we tested for weight change as a mediator, the association was no longer significant.This association appears to be mediated through concomitant weight change.

View Article: PubMed Central - PubMed

Affiliation: University of Maryland School of Public Health, College Park, Maryland, USA.

ABSTRACT

Introduction: The metabolic syndrome is the clustering of several cardiometabolic risk factors that can lead to the development of coronary heart disease and type 2 diabetes. We evaluated whether a change in aerobic fitness resulting from a lifestyle intervention could significantly change the odds of metabolic syndrome prevalence.

Methods: Participants (n = 810) were recruited into PREMIER, a multicenter, randomized, controlled clinical trial with outcome assessments at 6 and 18 months. The primary eligibility criterion was a diagnosis of prehypertension or stage 1 hypertension. PREMIER randomized participants to 2 lifestyle interventions, both of which included increased physical activity, or an advice-only control group. Participants completed a submaximal treadmill exercise test; we used reduction in heart rate as the measure of improved aerobic fitness. We used logistic regression to determine intervention effects on metabolic syndrome prevalence. Our models controlled for dietary pattern change.

Results: The lifestyle interventions had no significant effect on metabolic syndrome prevalence at 6 months or 18 months. When combining intervention and control groups, at 6 and 18 months, a 1-beat-per-minute reduction in heart rate was associated with a 4% reduction in prevalence of metabolic syndrome (P < .001). When we tested for weight change as a mediator, the association was no longer significant.

Conclusion: Increased aerobic fitness may reduce prevalence of metabolic syndrome. This association appears to be mediated through concomitant weight change.

Show MeSH
Related in: MedlinePlus