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Picolinic acid in patients with chronic hepatitis C infection: a preliminary report.

Zuwała-Jagiello J, Pazgan-Simon M, Simon K, Warwas M - Mediators Inflamm. (2012)

Bottom Line: The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation.Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P < 0.01 and P < 0.05, resp.).We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Poland. jagiellodr@interia.pl

ABSTRACT
Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P < 0.01 and P < 0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P < 0.01). The positive relationships were between PA and hsCRP levels (P < 0.05) and the presence of diabetes (P < 0.001). We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients.

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Related in: MedlinePlus

(a) Tryptophan (TRP) serum concentrations in 85 patients with chronic hepatitis C infection (CHC), according to child's stage of cirrhosis, and in a control group of 40 healthy blood donors. P values are given in the table. Comparisons between subgroups are illustrated with box plot graphics, where the dotted line indicates the median per group, the box represents 50% of the values, and horizontal lines show minimum and maximum values of the calculated nonoutlier values; asterisks and open circles indicate outlier values. (b) Kynurenine (KYN) serum concentrations decrease with the stage of liver cirrhosis in patients with CHC. However, in patients with Child-Pugh class A cirrhosis, the serum KYN was similar to those in healthy controls. P values are given in the table. (c) Picolinic acid (PA) serum concentrations increase with the stage of liver cirrhosis in patients with CHC. P values are given in the table.
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fig1: (a) Tryptophan (TRP) serum concentrations in 85 patients with chronic hepatitis C infection (CHC), according to child's stage of cirrhosis, and in a control group of 40 healthy blood donors. P values are given in the table. Comparisons between subgroups are illustrated with box plot graphics, where the dotted line indicates the median per group, the box represents 50% of the values, and horizontal lines show minimum and maximum values of the calculated nonoutlier values; asterisks and open circles indicate outlier values. (b) Kynurenine (KYN) serum concentrations decrease with the stage of liver cirrhosis in patients with CHC. However, in patients with Child-Pugh class A cirrhosis, the serum KYN was similar to those in healthy controls. P values are given in the table. (c) Picolinic acid (PA) serum concentrations increase with the stage of liver cirrhosis in patients with CHC. P values are given in the table.

Mentions: We analyzed 51 patients (23 males/17 females, median age 46 years, range 18–65 years) with chronic hepatitis C infection (CHC). The distribution of the stages of liver cirrhosis as defined according to the Child-Pugh score and measurements of tryptophan (TRP) and catabolites serum concentrations are presented in Figure 1. TRP and catabolites were also checked for correlations with selected biochemical markers of liver function (albumin, prothrombin ratio, and bilirubin concentration) and injury (aminotransferases).


Picolinic acid in patients with chronic hepatitis C infection: a preliminary report.

Zuwała-Jagiello J, Pazgan-Simon M, Simon K, Warwas M - Mediators Inflamm. (2012)

(a) Tryptophan (TRP) serum concentrations in 85 patients with chronic hepatitis C infection (CHC), according to child's stage of cirrhosis, and in a control group of 40 healthy blood donors. P values are given in the table. Comparisons between subgroups are illustrated with box plot graphics, where the dotted line indicates the median per group, the box represents 50% of the values, and horizontal lines show minimum and maximum values of the calculated nonoutlier values; asterisks and open circles indicate outlier values. (b) Kynurenine (KYN) serum concentrations decrease with the stage of liver cirrhosis in patients with CHC. However, in patients with Child-Pugh class A cirrhosis, the serum KYN was similar to those in healthy controls. P values are given in the table. (c) Picolinic acid (PA) serum concentrations increase with the stage of liver cirrhosis in patients with CHC. P values are given in the table.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368595&req=5

fig1: (a) Tryptophan (TRP) serum concentrations in 85 patients with chronic hepatitis C infection (CHC), according to child's stage of cirrhosis, and in a control group of 40 healthy blood donors. P values are given in the table. Comparisons between subgroups are illustrated with box plot graphics, where the dotted line indicates the median per group, the box represents 50% of the values, and horizontal lines show minimum and maximum values of the calculated nonoutlier values; asterisks and open circles indicate outlier values. (b) Kynurenine (KYN) serum concentrations decrease with the stage of liver cirrhosis in patients with CHC. However, in patients with Child-Pugh class A cirrhosis, the serum KYN was similar to those in healthy controls. P values are given in the table. (c) Picolinic acid (PA) serum concentrations increase with the stage of liver cirrhosis in patients with CHC. P values are given in the table.
Mentions: We analyzed 51 patients (23 males/17 females, median age 46 years, range 18–65 years) with chronic hepatitis C infection (CHC). The distribution of the stages of liver cirrhosis as defined according to the Child-Pugh score and measurements of tryptophan (TRP) and catabolites serum concentrations are presented in Figure 1. TRP and catabolites were also checked for correlations with selected biochemical markers of liver function (albumin, prothrombin ratio, and bilirubin concentration) and injury (aminotransferases).

Bottom Line: The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation.Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P < 0.01 and P < 0.05, resp.).We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Poland. jagiellodr@interia.pl

ABSTRACT
Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P < 0.01 and P < 0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P < 0.01). The positive relationships were between PA and hsCRP levels (P < 0.05) and the presence of diabetes (P < 0.001). We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients.

Show MeSH
Related in: MedlinePlus