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Comparison of retinal nerve fiber layer thickness measurements in healthy subjects using fourier and time domain optical coherence tomography.

Pinilla I, Garcia-Martin E, Idoipe M, Sancho E, Fuertes I - J Ophthalmol (2012)

Bottom Line: Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods.Conclusions.Measurements obtained using Fourier domain device show better reproducibility.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, 50009 Zaragoza, Spain.

ABSTRACT
Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain measurements in healthy subjects. Methods. One hundred and thirty-two eyes of 132 healthy subjects were scaned on the same day with both instruments, separated by 10 minutes from each other. Thickness of quadrant, average and the 12 different areas around the optic nerve were compared between Cirrus and Stratus. Repeatability, intraclass correlation coefficients (ICCs), and coefficients of variation (COVs) were calculated in RNFL measurements provided by Fourier domain device. Results. The average thickness in the optic cube was 95.50 μm using Cirrus and 97.85 μm using Stratus. Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods. Reproducibility was better with Fourier domain OCT (mean COV of 4.54%) than with Stratus time-domain OCT (mean COV of 5.57%). Conclusions. Both scan options give reproducible RNFL thickness measurement, but there are differences between them. Measurements obtained using Fourier domain device show better reproducibility.

No MeSH data available.


Related in: MedlinePlus

Bland-Altman plots of the agreement in retinal nerve fiber layer (RNFL) thickness between Cirrus HD OCT measurement 1 and Cirrus HD OCT measurement 2. The difference (Cirrus HD OCT average RNFL thickness measurement 1 minus Cirrus HD OCT average RNFL thickness measurement 2) was plotted against the average of the three measurements for the average RNFL thickness Cirrus HD OCT measurements. SD: standard deviation.
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fig2: Bland-Altman plots of the agreement in retinal nerve fiber layer (RNFL) thickness between Cirrus HD OCT measurement 1 and Cirrus HD OCT measurement 2. The difference (Cirrus HD OCT average RNFL thickness measurement 1 minus Cirrus HD OCT average RNFL thickness measurement 2) was plotted against the average of the three measurements for the average RNFL thickness Cirrus HD OCT measurements. SD: standard deviation.

Mentions: Reproducibility is presented in Table 2. Bland-Altman plots were made depicting the agreement between different Cirrus HD OCT RNFL thickness measurements (Figure 2) and Stratus measurements (Figure 3). The difference between Cirrus HD OCT measurements (first Cirrus HD OCT RNFL thickness-second Cirrus HD OCT RNFL thickness) was plotted against the average of the three Cirrus HD OCT measurements for the RNFL thickness (Figure 2). The scatterplots demonstrate the agreement of the measurements. More than 90% of the measurements were between ±5 microns differences (Figures 2 and 3). These small differences were not related to the average RNFL thickness and were similar in those with thinner or smaller thickness. Variability of RNFL measurements was higher with Stratus OCT, as is shown in Tables 1 and 2, and Figure 3.


Comparison of retinal nerve fiber layer thickness measurements in healthy subjects using fourier and time domain optical coherence tomography.

Pinilla I, Garcia-Martin E, Idoipe M, Sancho E, Fuertes I - J Ophthalmol (2012)

Bland-Altman plots of the agreement in retinal nerve fiber layer (RNFL) thickness between Cirrus HD OCT measurement 1 and Cirrus HD OCT measurement 2. The difference (Cirrus HD OCT average RNFL thickness measurement 1 minus Cirrus HD OCT average RNFL thickness measurement 2) was plotted against the average of the three measurements for the average RNFL thickness Cirrus HD OCT measurements. SD: standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3368551&req=5

fig2: Bland-Altman plots of the agreement in retinal nerve fiber layer (RNFL) thickness between Cirrus HD OCT measurement 1 and Cirrus HD OCT measurement 2. The difference (Cirrus HD OCT average RNFL thickness measurement 1 minus Cirrus HD OCT average RNFL thickness measurement 2) was plotted against the average of the three measurements for the average RNFL thickness Cirrus HD OCT measurements. SD: standard deviation.
Mentions: Reproducibility is presented in Table 2. Bland-Altman plots were made depicting the agreement between different Cirrus HD OCT RNFL thickness measurements (Figure 2) and Stratus measurements (Figure 3). The difference between Cirrus HD OCT measurements (first Cirrus HD OCT RNFL thickness-second Cirrus HD OCT RNFL thickness) was plotted against the average of the three Cirrus HD OCT measurements for the RNFL thickness (Figure 2). The scatterplots demonstrate the agreement of the measurements. More than 90% of the measurements were between ±5 microns differences (Figures 2 and 3). These small differences were not related to the average RNFL thickness and were similar in those with thinner or smaller thickness. Variability of RNFL measurements was higher with Stratus OCT, as is shown in Tables 1 and 2, and Figure 3.

Bottom Line: Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods.Conclusions.Measurements obtained using Fourier domain device show better reproducibility.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, 50009 Zaragoza, Spain.

ABSTRACT
Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain measurements in healthy subjects. Methods. One hundred and thirty-two eyes of 132 healthy subjects were scaned on the same day with both instruments, separated by 10 minutes from each other. Thickness of quadrant, average and the 12 different areas around the optic nerve were compared between Cirrus and Stratus. Repeatability, intraclass correlation coefficients (ICCs), and coefficients of variation (COVs) were calculated in RNFL measurements provided by Fourier domain device. Results. The average thickness in the optic cube was 95.50 μm using Cirrus and 97.85 μm using Stratus. Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods. Reproducibility was better with Fourier domain OCT (mean COV of 4.54%) than with Stratus time-domain OCT (mean COV of 5.57%). Conclusions. Both scan options give reproducible RNFL thickness measurement, but there are differences between them. Measurements obtained using Fourier domain device show better reproducibility.

No MeSH data available.


Related in: MedlinePlus