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Comparison of retinal nerve fiber layer thickness measurements in healthy subjects using fourier and time domain optical coherence tomography.

Pinilla I, Garcia-Martin E, Idoipe M, Sancho E, Fuertes I - J Ophthalmol (2012)

Bottom Line: Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods.Conclusions.Measurements obtained using Fourier domain device show better reproducibility.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, 50009 Zaragoza, Spain.

ABSTRACT
Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain measurements in healthy subjects. Methods. One hundred and thirty-two eyes of 132 healthy subjects were scaned on the same day with both instruments, separated by 10 minutes from each other. Thickness of quadrant, average and the 12 different areas around the optic nerve were compared between Cirrus and Stratus. Repeatability, intraclass correlation coefficients (ICCs), and coefficients of variation (COVs) were calculated in RNFL measurements provided by Fourier domain device. Results. The average thickness in the optic cube was 95.50 μm using Cirrus and 97.85 μm using Stratus. Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods. Reproducibility was better with Fourier domain OCT (mean COV of 4.54%) than with Stratus time-domain OCT (mean COV of 5.57%). Conclusions. Both scan options give reproducible RNFL thickness measurement, but there are differences between them. Measurements obtained using Fourier domain device show better reproducibility.

No MeSH data available.


Related in: MedlinePlus

Representation for retinal nerve fiber layer thicknesses in the four quadrants using Cirrus HD and Stratus OCT devices. Measurements were higher with Cirrus OCT.
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fig1: Representation for retinal nerve fiber layer thicknesses in the four quadrants using Cirrus HD and Stratus OCT devices. Measurements were higher with Cirrus OCT.

Mentions: Table 1 gives the mean values and standard deviation of the RNFL in global thickness and in each parapapillary quadrant in all the subjects. Significant differences were found in the global thickness using both instruments; this value was 2.37 microns superior with Stratus than with Cirrus HD OCT (P = 0.003). Significant differences were only found between the temporal quadrants measurements with both instruments (2.21 μm higher using Stratus; P = 0.046). When the different 12 segments around the optic disc were analyzed, we found significant differences in sectors H1, H4, H5, H8, H11, and H12 (see Table 1). The quadrant thickness differences between both OCT devices are shown in Figure 1. The graph demonstrates that measurements of RNFL thickness were thicker with the Stratus OCT than with the Cirrus HD OCT. Also, the inspection of the plots reveals discrepancy between RNFL thickness measurements obtained by both OCT instruments.


Comparison of retinal nerve fiber layer thickness measurements in healthy subjects using fourier and time domain optical coherence tomography.

Pinilla I, Garcia-Martin E, Idoipe M, Sancho E, Fuertes I - J Ophthalmol (2012)

Representation for retinal nerve fiber layer thicknesses in the four quadrants using Cirrus HD and Stratus OCT devices. Measurements were higher with Cirrus OCT.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368551&req=5

fig1: Representation for retinal nerve fiber layer thicknesses in the four quadrants using Cirrus HD and Stratus OCT devices. Measurements were higher with Cirrus OCT.
Mentions: Table 1 gives the mean values and standard deviation of the RNFL in global thickness and in each parapapillary quadrant in all the subjects. Significant differences were found in the global thickness using both instruments; this value was 2.37 microns superior with Stratus than with Cirrus HD OCT (P = 0.003). Significant differences were only found between the temporal quadrants measurements with both instruments (2.21 μm higher using Stratus; P = 0.046). When the different 12 segments around the optic disc were analyzed, we found significant differences in sectors H1, H4, H5, H8, H11, and H12 (see Table 1). The quadrant thickness differences between both OCT devices are shown in Figure 1. The graph demonstrates that measurements of RNFL thickness were thicker with the Stratus OCT than with the Cirrus HD OCT. Also, the inspection of the plots reveals discrepancy between RNFL thickness measurements obtained by both OCT instruments.

Bottom Line: Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods.Conclusions.Measurements obtained using Fourier domain device show better reproducibility.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, 50009 Zaragoza, Spain.

ABSTRACT
Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain measurements in healthy subjects. Methods. One hundred and thirty-two eyes of 132 healthy subjects were scaned on the same day with both instruments, separated by 10 minutes from each other. Thickness of quadrant, average and the 12 different areas around the optic nerve were compared between Cirrus and Stratus. Repeatability, intraclass correlation coefficients (ICCs), and coefficients of variation (COVs) were calculated in RNFL measurements provided by Fourier domain device. Results. The average thickness in the optic cube was 95.50 μm using Cirrus and 97.85 μm using Stratus. Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods. Reproducibility was better with Fourier domain OCT (mean COV of 4.54%) than with Stratus time-domain OCT (mean COV of 5.57%). Conclusions. Both scan options give reproducible RNFL thickness measurement, but there are differences between them. Measurements obtained using Fourier domain device show better reproducibility.

No MeSH data available.


Related in: MedlinePlus