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Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae).

Agyare C, Koffuor GA, Boamah VE, Adu F, Mensah KB, Adu-Amoah L - Evid Based Complement Alternat Med (2012)

Bottom Line: This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks.The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL.All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

ABSTRACT
Pterygota macrocarpa and Cola gigantea are African medicinal plants used in traditional medicine for the treatment of sores, skin infections, and other inflammatory conditions including pains. This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks. The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL. Extracts with concentration of 50 mg/mL were most active against the test organisms according to the agar diffusion method. All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001).

No MeSH data available.


Related in: MedlinePlus

Effects of Ethanol stem bark extract (CGBE) of C. gigantea (30–300 mg/kg) on carrageenan-induced paw oedema. Values are expressed as mean ± SEM (N = 5), significantly different from control. **P < 0.05, **P < 0.01, and ***P < 0.001. Control is the untreated birds.
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fig4: Effects of Ethanol stem bark extract (CGBE) of C. gigantea (30–300 mg/kg) on carrageenan-induced paw oedema. Values are expressed as mean ± SEM (N = 5), significantly different from control. **P < 0.05, **P < 0.01, and ***P < 0.001. Control is the untreated birds.

Mentions: All the animals injected with carrageenan exhibited acute inflammation which manifested as increased foot volume. The control group however showed increased inflammation till the fourth hour. All the extract-treated groups except CGLE- (F3,80 = 1.80, P = 0.1545: Figure 3) treated group exhibited significant anti-inflammatory effects (PMLE: F3,80 = 47.52, P < 0.0001; PMBE: F3,80 = 35.58, P < 0.001; CGBE: F3,80  =  1.80, P = 0.1545: Figures 1, 2, and 4). Similar effects were observed after treating the animals with diclofenac (F3,80 = 79.81, P < 0.0001) and dexamethasone (F3,80 = 90.49, P < 0.0001) used as positive controls (Figure 5).


Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae).

Agyare C, Koffuor GA, Boamah VE, Adu F, Mensah KB, Adu-Amoah L - Evid Based Complement Alternat Med (2012)

Effects of Ethanol stem bark extract (CGBE) of C. gigantea (30–300 mg/kg) on carrageenan-induced paw oedema. Values are expressed as mean ± SEM (N = 5), significantly different from control. **P < 0.05, **P < 0.01, and ***P < 0.001. Control is the untreated birds.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368549&req=5

fig4: Effects of Ethanol stem bark extract (CGBE) of C. gigantea (30–300 mg/kg) on carrageenan-induced paw oedema. Values are expressed as mean ± SEM (N = 5), significantly different from control. **P < 0.05, **P < 0.01, and ***P < 0.001. Control is the untreated birds.
Mentions: All the animals injected with carrageenan exhibited acute inflammation which manifested as increased foot volume. The control group however showed increased inflammation till the fourth hour. All the extract-treated groups except CGLE- (F3,80 = 1.80, P = 0.1545: Figure 3) treated group exhibited significant anti-inflammatory effects (PMLE: F3,80 = 47.52, P < 0.0001; PMBE: F3,80 = 35.58, P < 0.001; CGBE: F3,80  =  1.80, P = 0.1545: Figures 1, 2, and 4). Similar effects were observed after treating the animals with diclofenac (F3,80 = 79.81, P < 0.0001) and dexamethasone (F3,80 = 90.49, P < 0.0001) used as positive controls (Figure 5).

Bottom Line: This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks.The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL.All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

ABSTRACT
Pterygota macrocarpa and Cola gigantea are African medicinal plants used in traditional medicine for the treatment of sores, skin infections, and other inflammatory conditions including pains. This study therefore aims at investigating the antimicrobial properties of ethanol leaf and stem bark extracts of P. macrocarpa and C. gigantea using the agar diffusion and the micro-dilution techniques and also determining the anti-inflammatory properties of the extracts of these plants in carrageenan-induced foot edema in seven-day old chicks. The minimum inhibitory concentration of both ethanol leaf and bark extracts of P. macrocarpa against the test organisms was from 0.125 to 2.55 mg/mL and that of C. gigantea extracts was 0.125 to 2.75 mg/mL. Extracts with concentration of 50 mg/mL were most active against the test organisms according to the agar diffusion method. All the extracts of P. macrocarpa and C. gigantea at 30, 100, and 300 mg/kg body weight except ethanol leaf extract of C. gigantea exhibited significant anti-inflammatory effects (P ≤ 0.001).

No MeSH data available.


Related in: MedlinePlus