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Polyphenols: key issues involved in chemoprevention of prostate cancer.

Cimino S, Sortino G, Favilla V, Castelli T, Madonia M, Sansalone S, Russo GI, Morgia G - Oxid Med Cell Longev (2012)

Bottom Line: Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population.Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer.This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, University of Catania, 95125 Catania, Italy. ciminonello@hotmail.com

ABSTRACT
Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.

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Related in: MedlinePlus

Genistein.
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fig5: Genistein.

Mentions: Genistein (4′,5,7-trihydroxyisoflavone), the predominant isoflavone in human nutrition, is derived mainly from soybeans but also from other legumes, including peas, lentils, or beans (Figure 5) [38].


Polyphenols: key issues involved in chemoprevention of prostate cancer.

Cimino S, Sortino G, Favilla V, Castelli T, Madonia M, Sansalone S, Russo GI, Morgia G - Oxid Med Cell Longev (2012)

Genistein.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368543&req=5

fig5: Genistein.
Mentions: Genistein (4′,5,7-trihydroxyisoflavone), the predominant isoflavone in human nutrition, is derived mainly from soybeans but also from other legumes, including peas, lentils, or beans (Figure 5) [38].

Bottom Line: Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population.Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer.This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, University of Catania, 95125 Catania, Italy. ciminonello@hotmail.com

ABSTRACT
Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.

Show MeSH
Related in: MedlinePlus