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Curcumin and other polyphenolic compounds in head and neck cancer chemoprevention.

Baumeister P, Reiter M, Harréus U - Oxid Med Cell Longev (2012)

Bottom Line: In this regard polyphenols came into focus, not only because of their antioxidant potential but also because of their ability to interact with molecular targets within the cells.Because polyphenols occur in many foods and beverages in high concentration and evidence for their anticancer activity is best for tissues they can come into direct contact with, field cancerization predestines upper aerodigestive tract epithelium for cancer chemoprevention by polyphenols.We present data regarding antimutagenic effects of curcumin and epigallocatechin-3-gallate in human oropharyngeal mucosa cultures exposed to cigarette smoke condensate.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377 Munich, Germany. philipp.baumeister@med.uni-muenchen.de

ABSTRACT
Despite clear results of observational studies linking a diet rich in fruits and vegetables to a decreased cancer risk, large interventional trials evaluating the impact of dietary micronutrient supplementation, mostly vitamins, could not show any beneficial effects. Today it has become clear that a single micronutrient, given in supernutritional doses, cannot match cancer preventive effects of whole fruits and vegetables. In this regard polyphenols came into focus, not only because of their antioxidant potential but also because of their ability to interact with molecular targets within the cells. Because polyphenols occur in many foods and beverages in high concentration and evidence for their anticancer activity is best for tissues they can come into direct contact with, field cancerization predestines upper aerodigestive tract epithelium for cancer chemoprevention by polyphenols. In this paper, we summarize cancer chemopreventive attempts with emphasis on head and neck carcinogenesis and discuss some methodological issues. We present data regarding antimutagenic effects of curcumin and epigallocatechin-3-gallate in human oropharyngeal mucosa cultures exposed to cigarette smoke condensate.

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Related in: MedlinePlus

DNA damage (% tail DNA) caused by cigarette smoke condensate (CSC), after previous incubation with Curcumin on 1 day or on 4 days (n = 20; o = outlier value, * = extreme value; α-level = 0.02).
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Related In: Results  -  Collection


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fig1: DNA damage (% tail DNA) caused by cigarette smoke condensate (CSC), after previous incubation with Curcumin on 1 day or on 4 days (n = 20; o = outlier value, * = extreme value; α-level = 0.02).

Mentions: In the first experimental arm, DMSO used as the solvent for all other chemicals, as well as curcumin added on 1 or 4 days, did not cause considerable DNA damage. CSC did induce DNA fragmentation mean % tail DNA was 19.1. Previous exposure to curcumin within 60 minutes led to a reduction of DNA damage by 31.4% to 13.1% tail DNA. When cultures were incubated with curcumin on 4 days, DNA fragmentation was reduced by 47% to 10.1% tail DNA, which reflects a significant further decrease of CSC-induced genotoxicity (see Figure 1).


Curcumin and other polyphenolic compounds in head and neck cancer chemoprevention.

Baumeister P, Reiter M, Harréus U - Oxid Med Cell Longev (2012)

DNA damage (% tail DNA) caused by cigarette smoke condensate (CSC), after previous incubation with Curcumin on 1 day or on 4 days (n = 20; o = outlier value, * = extreme value; α-level = 0.02).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368521&req=5

fig1: DNA damage (% tail DNA) caused by cigarette smoke condensate (CSC), after previous incubation with Curcumin on 1 day or on 4 days (n = 20; o = outlier value, * = extreme value; α-level = 0.02).
Mentions: In the first experimental arm, DMSO used as the solvent for all other chemicals, as well as curcumin added on 1 or 4 days, did not cause considerable DNA damage. CSC did induce DNA fragmentation mean % tail DNA was 19.1. Previous exposure to curcumin within 60 minutes led to a reduction of DNA damage by 31.4% to 13.1% tail DNA. When cultures were incubated with curcumin on 4 days, DNA fragmentation was reduced by 47% to 10.1% tail DNA, which reflects a significant further decrease of CSC-induced genotoxicity (see Figure 1).

Bottom Line: In this regard polyphenols came into focus, not only because of their antioxidant potential but also because of their ability to interact with molecular targets within the cells.Because polyphenols occur in many foods and beverages in high concentration and evidence for their anticancer activity is best for tissues they can come into direct contact with, field cancerization predestines upper aerodigestive tract epithelium for cancer chemoprevention by polyphenols.We present data regarding antimutagenic effects of curcumin and epigallocatechin-3-gallate in human oropharyngeal mucosa cultures exposed to cigarette smoke condensate.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377 Munich, Germany. philipp.baumeister@med.uni-muenchen.de

ABSTRACT
Despite clear results of observational studies linking a diet rich in fruits and vegetables to a decreased cancer risk, large interventional trials evaluating the impact of dietary micronutrient supplementation, mostly vitamins, could not show any beneficial effects. Today it has become clear that a single micronutrient, given in supernutritional doses, cannot match cancer preventive effects of whole fruits and vegetables. In this regard polyphenols came into focus, not only because of their antioxidant potential but also because of their ability to interact with molecular targets within the cells. Because polyphenols occur in many foods and beverages in high concentration and evidence for their anticancer activity is best for tissues they can come into direct contact with, field cancerization predestines upper aerodigestive tract epithelium for cancer chemoprevention by polyphenols. In this paper, we summarize cancer chemopreventive attempts with emphasis on head and neck carcinogenesis and discuss some methodological issues. We present data regarding antimutagenic effects of curcumin and epigallocatechin-3-gallate in human oropharyngeal mucosa cultures exposed to cigarette smoke condensate.

Show MeSH
Related in: MedlinePlus