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Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.

Wang Y, Zi XY, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP - Int J Nanomedicine (2012)

Bottom Line: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects.Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis.CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China.

ABSTRACT
In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.

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Cell cycle progression assay of HeLa cells treated with different concentrations of CONPs for 48 hours.Notes: Proliferation of HeLa cells was strongly suppressed by CONPs in a dose-dependent manner. Cells were arrested in the G1/G0 phase after 48 hours of treatment and were less able to proliferate.Abbreviation: CONPs, cuprous oxide nanoparticles.
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f7-ijn-7-2641: Cell cycle progression assay of HeLa cells treated with different concentrations of CONPs for 48 hours.Notes: Proliferation of HeLa cells was strongly suppressed by CONPs in a dose-dependent manner. Cells were arrested in the G1/G0 phase after 48 hours of treatment and were less able to proliferate.Abbreviation: CONPs, cuprous oxide nanoparticles.

Mentions: Cell cycle progression analysis was performed and showed that HeLa cells were arrested strongly by CONPs in a dose-dependent manner. Approximately 58% of cells exposed to 10 μg/mL of CONPs and 80% of cells exposed to 20 μg/mL of CONPs were arrested in G1/G0 48 hours after CONPs exposure (Figure 7). Furthermore, the number of cells in S phase decreased as the concentration of CONPs increased. However, the iron-core gold-shell nanoparticles also suppressed cell proliferation and cells were delayed in S phase,16 whereas the cells exposed to CONPs were delayed in G1/G0. Furthermore, treatment with Ag nanoparticles caused a cell cycle arrest in G2/M phase, possibly due to the repair of damaged DNA.34 These results show that different nanoparticles have different effects on the cell cycle, which may be important in exploring the mechanism of their biological actions.


Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.

Wang Y, Zi XY, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP - Int J Nanomedicine (2012)

Cell cycle progression assay of HeLa cells treated with different concentrations of CONPs for 48 hours.Notes: Proliferation of HeLa cells was strongly suppressed by CONPs in a dose-dependent manner. Cells were arrested in the G1/G0 phase after 48 hours of treatment and were less able to proliferate.Abbreviation: CONPs, cuprous oxide nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368515&req=5

f7-ijn-7-2641: Cell cycle progression assay of HeLa cells treated with different concentrations of CONPs for 48 hours.Notes: Proliferation of HeLa cells was strongly suppressed by CONPs in a dose-dependent manner. Cells were arrested in the G1/G0 phase after 48 hours of treatment and were less able to proliferate.Abbreviation: CONPs, cuprous oxide nanoparticles.
Mentions: Cell cycle progression analysis was performed and showed that HeLa cells were arrested strongly by CONPs in a dose-dependent manner. Approximately 58% of cells exposed to 10 μg/mL of CONPs and 80% of cells exposed to 20 μg/mL of CONPs were arrested in G1/G0 48 hours after CONPs exposure (Figure 7). Furthermore, the number of cells in S phase decreased as the concentration of CONPs increased. However, the iron-core gold-shell nanoparticles also suppressed cell proliferation and cells were delayed in S phase,16 whereas the cells exposed to CONPs were delayed in G1/G0. Furthermore, treatment with Ag nanoparticles caused a cell cycle arrest in G2/M phase, possibly due to the repair of damaged DNA.34 These results show that different nanoparticles have different effects on the cell cycle, which may be important in exploring the mechanism of their biological actions.

Bottom Line: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects.Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis.CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China.

ABSTRACT
In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.

Show MeSH
Related in: MedlinePlus