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Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.

Wang Y, Zi XY, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP - Int J Nanomedicine (2012)

Bottom Line: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects.Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis.CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China.

ABSTRACT
In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.

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UV-vis spectra of the CONPs.Note: CONPs were dissolved in deionized water and deionized water was used as a reference.Abbreviation: CONPs, cuprous oxide nanoparticles.
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f2-ijn-7-2641: UV-vis spectra of the CONPs.Note: CONPs were dissolved in deionized water and deionized water was used as a reference.Abbreviation: CONPs, cuprous oxide nanoparticles.

Mentions: The XRD patterns (Figure 1) showed that the CONPs were crystalline, and the diffraction pattern and interplanar spacing of the CONPs were similar to those in the standard diffraction pattern of cuprous oxide.22 Furthermore, no characteristic peaks of impurities were detected, suggesting that high-quality CONPs were obtained. The UV-vis spectrum of the CONPs showed a wide absorption band between 200 nm and 500 nm (Figure 2). Figure 3 presents the FTIR spectra of the CONPs, showing their composition and quality. The band at 624 cm−1 correlates with the stretching vibrations of cuprous oxide. The bands at approximately 2922 cm−1 and 1373 cm−1 are probably due to the carbonate moieties, water, or other organic compounds in the air that were adsorbed by the CONPs, as these bands are generally observed when FTIR samples are measured in air.15 The TEM images showed that the CONPs were all spherical and homogeneous (Figure 4). The diameter of the CONPs in the suspensions ranged from approximately 40 nm to 110 nm (Figure S1). From our characterization of the CONPs, we can see that the CONPs prepared in our experiment were of good quality.


Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.

Wang Y, Zi XY, Su J, Zhang HX, Zhang XR, Zhu HY, Li JX, Yin M, Yang F, Hu YP - Int J Nanomedicine (2012)

UV-vis spectra of the CONPs.Note: CONPs were dissolved in deionized water and deionized water was used as a reference.Abbreviation: CONPs, cuprous oxide nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368515&req=5

f2-ijn-7-2641: UV-vis spectra of the CONPs.Note: CONPs were dissolved in deionized water and deionized water was used as a reference.Abbreviation: CONPs, cuprous oxide nanoparticles.
Mentions: The XRD patterns (Figure 1) showed that the CONPs were crystalline, and the diffraction pattern and interplanar spacing of the CONPs were similar to those in the standard diffraction pattern of cuprous oxide.22 Furthermore, no characteristic peaks of impurities were detected, suggesting that high-quality CONPs were obtained. The UV-vis spectrum of the CONPs showed a wide absorption band between 200 nm and 500 nm (Figure 2). Figure 3 presents the FTIR spectra of the CONPs, showing their composition and quality. The band at 624 cm−1 correlates with the stretching vibrations of cuprous oxide. The bands at approximately 2922 cm−1 and 1373 cm−1 are probably due to the carbonate moieties, water, or other organic compounds in the air that were adsorbed by the CONPs, as these bands are generally observed when FTIR samples are measured in air.15 The TEM images showed that the CONPs were all spherical and homogeneous (Figure 4). The diameter of the CONPs in the suspensions ranged from approximately 40 nm to 110 nm (Figure S1). From our characterization of the CONPs, we can see that the CONPs prepared in our experiment were of good quality.

Bottom Line: In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects.Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis.CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China.

ABSTRACT
In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.

Show MeSH
Related in: MedlinePlus