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A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.

Shi HS, Gao X, Li D, Zhang QW, Wang YS, Zheng Y, Cai LL, Zhong RM, Rui A, Li ZY, Zheng H, Chen XC, Chen LJ - Int J Nanomedicine (2012)

Bottom Line: The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model.The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation.This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China.

ABSTRACT
Radiation pneumonitis (RP) is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL)-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation. This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

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Related in: MedlinePlus

The effects of the treatment with Lipo-cur on body weight and life span. Normal C57BL/6J mice (7 weeks old, 20 mice per group) were treated intravenously with Lipo-cur (5 mg/kg), and NS was injected into each group through the tail vein. The injections were continued for 7 days, but mice were not challenged with tumor cells. Mice in each group were investigated for potential toxicity for 6 months. (A) There was no weight loss in the mice treated with Lipo-cur, compared with control groups (P > 0.05). The results are expressed as mean weight, and error bars represent ± standard error of the mean. (B) There was no decrease in life span in the mice treated with Lipo-cur, compared with the control groups (P > 0.05).Note: Data represent percentage of survival at day 180 after the treatment.Abbreviations: Lipo-cur, liposomal curcumin; NS, normal saline.
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f2-ijn-7-2601: The effects of the treatment with Lipo-cur on body weight and life span. Normal C57BL/6J mice (7 weeks old, 20 mice per group) were treated intravenously with Lipo-cur (5 mg/kg), and NS was injected into each group through the tail vein. The injections were continued for 7 days, but mice were not challenged with tumor cells. Mice in each group were investigated for potential toxicity for 6 months. (A) There was no weight loss in the mice treated with Lipo-cur, compared with control groups (P > 0.05). The results are expressed as mean weight, and error bars represent ± standard error of the mean. (B) There was no decrease in life span in the mice treated with Lipo-cur, compared with the control groups (P > 0.05).Note: Data represent percentage of survival at day 180 after the treatment.Abbreviations: Lipo-cur, liposomal curcumin; NS, normal saline.

Mentions: The mice treated with Lipo-cur were in particular investigated for the potential long-term toxicity. No adverse consequences were indicated in gross measures such as weight loss (Figure 2A), ruffling of fur, or life-span (Figure 2B). Furthermore, no pathologic changes of liver, kidney, lung, spleen, or brain were found by the microscopic examination (data not shown).


A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.

Shi HS, Gao X, Li D, Zhang QW, Wang YS, Zheng Y, Cai LL, Zhong RM, Rui A, Li ZY, Zheng H, Chen XC, Chen LJ - Int J Nanomedicine (2012)

The effects of the treatment with Lipo-cur on body weight and life span. Normal C57BL/6J mice (7 weeks old, 20 mice per group) were treated intravenously with Lipo-cur (5 mg/kg), and NS was injected into each group through the tail vein. The injections were continued for 7 days, but mice were not challenged with tumor cells. Mice in each group were investigated for potential toxicity for 6 months. (A) There was no weight loss in the mice treated with Lipo-cur, compared with control groups (P > 0.05). The results are expressed as mean weight, and error bars represent ± standard error of the mean. (B) There was no decrease in life span in the mice treated with Lipo-cur, compared with the control groups (P > 0.05).Note: Data represent percentage of survival at day 180 after the treatment.Abbreviations: Lipo-cur, liposomal curcumin; NS, normal saline.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368513&req=5

f2-ijn-7-2601: The effects of the treatment with Lipo-cur on body weight and life span. Normal C57BL/6J mice (7 weeks old, 20 mice per group) were treated intravenously with Lipo-cur (5 mg/kg), and NS was injected into each group through the tail vein. The injections were continued for 7 days, but mice were not challenged with tumor cells. Mice in each group were investigated for potential toxicity for 6 months. (A) There was no weight loss in the mice treated with Lipo-cur, compared with control groups (P > 0.05). The results are expressed as mean weight, and error bars represent ± standard error of the mean. (B) There was no decrease in life span in the mice treated with Lipo-cur, compared with the control groups (P > 0.05).Note: Data represent percentage of survival at day 180 after the treatment.Abbreviations: Lipo-cur, liposomal curcumin; NS, normal saline.
Mentions: The mice treated with Lipo-cur were in particular investigated for the potential long-term toxicity. No adverse consequences were indicated in gross measures such as weight loss (Figure 2A), ruffling of fur, or life-span (Figure 2B). Furthermore, no pathologic changes of liver, kidney, lung, spleen, or brain were found by the microscopic examination (data not shown).

Bottom Line: The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model.The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation.This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China.

ABSTRACT
Radiation pneumonitis (RP) is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL)-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation. This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

Show MeSH
Related in: MedlinePlus