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A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.

Shi HS, Gao X, Li D, Zhang QW, Wang YS, Zheng Y, Cai LL, Zhong RM, Rui A, Li ZY, Zheng H, Chen XC, Chen LJ - Int J Nanomedicine (2012)

Bottom Line: The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model.The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation.This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China.

ABSTRACT
Radiation pneumonitis (RP) is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL)-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation. This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

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Related in: MedlinePlus

Preparation and characterization of Lipo-cur. (A) Preparation scheme of Lipo-cur. (B) Size distribution of Lipo-cur. (C) Zeta potential of Lipo-cur. (D) Photographs of curcumin phosphate-buffered solution, Lipo-cur, and curcumin ethanol solution (from left to right). (E) Transmission electron microscopy image of Lipo-cur.Abbreviations: Cur, curcumin; Lipo-cur, liposomal curcumin.
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f1-ijn-7-2601: Preparation and characterization of Lipo-cur. (A) Preparation scheme of Lipo-cur. (B) Size distribution of Lipo-cur. (C) Zeta potential of Lipo-cur. (D) Photographs of curcumin phosphate-buffered solution, Lipo-cur, and curcumin ethanol solution (from left to right). (E) Transmission electron microscopy image of Lipo-cur.Abbreviations: Cur, curcumin; Lipo-cur, liposomal curcumin.

Mentions: The appearance of curcumin aqueous solution, Lipo-cur, and curcumin ethanol solution are shown in Figure 1D. As curcumin is water-insoluble, its PBS solution was turbid. In contrast, the Lipo-cur solution was a translucent, yellow dispersion without sedimentation. The curcumin ethanol solution was clear and transparent.


A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation.

Shi HS, Gao X, Li D, Zhang QW, Wang YS, Zheng Y, Cai LL, Zhong RM, Rui A, Li ZY, Zheng H, Chen XC, Chen LJ - Int J Nanomedicine (2012)

Preparation and characterization of Lipo-cur. (A) Preparation scheme of Lipo-cur. (B) Size distribution of Lipo-cur. (C) Zeta potential of Lipo-cur. (D) Photographs of curcumin phosphate-buffered solution, Lipo-cur, and curcumin ethanol solution (from left to right). (E) Transmission electron microscopy image of Lipo-cur.Abbreviations: Cur, curcumin; Lipo-cur, liposomal curcumin.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368513&req=5

f1-ijn-7-2601: Preparation and characterization of Lipo-cur. (A) Preparation scheme of Lipo-cur. (B) Size distribution of Lipo-cur. (C) Zeta potential of Lipo-cur. (D) Photographs of curcumin phosphate-buffered solution, Lipo-cur, and curcumin ethanol solution (from left to right). (E) Transmission electron microscopy image of Lipo-cur.Abbreviations: Cur, curcumin; Lipo-cur, liposomal curcumin.
Mentions: The appearance of curcumin aqueous solution, Lipo-cur, and curcumin ethanol solution are shown in Figure 1D. As curcumin is water-insoluble, its PBS solution was turbid. In contrast, the Lipo-cur solution was a translucent, yellow dispersion without sedimentation. The curcumin ethanol solution was clear and transparent.

Bottom Line: The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model.The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation.This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China.

ABSTRACT
Radiation pneumonitis (RP) is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL)-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation. This study also suggests that the systemic administration of liposomal curcumin is safe and deserves to be investigated for further clinical application.

Show MeSH
Related in: MedlinePlus