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Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO(2) Reactivity in Normal Subjects.

Jung WS, Park JY, Byeon HS, Kim YJ, Park JM, Park SU, Cho SY, Moon SK - Evid Based Complement Alternat Med (2012)

Bottom Line: HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus -8.1 ± 4.1%, P = 0.007).The mean blood pressure and pulse rate did not vary from baseline values in either group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea.

ABSTRACT
Aim. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO(2) reactivity (CVR) in healthy male subjects. Materials and Methods. We examined erythrocyte deformability in an HCEt group (n = 14) and a control group (n = 10). CVR was measured using hyperventilation-induced CO(2) reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group (n = 11). A historical control group (n = 10) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (2.9 ± 1.1% versus -0.6 ± 1.0%, P = 0.034). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus -8.1 ± 4.1%, P = 0.007). The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt's effect on cerebral microcirculation.

No MeSH data available.


Related in: MedlinePlus

Change of erythrocyte deformability in the HCEt group (n = 14) and the control group (n = 10) at each time point. All values are the percent change compared to baseline. The vertical bars represent the means ± S.E.M. The P values were obtained from independent t-test. HCEt: hyul-bu-chuke-tang; h: hour. #P < 0.05 compared to the control group.
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fig1: Change of erythrocyte deformability in the HCEt group (n = 14) and the control group (n = 10) at each time point. All values are the percent change compared to baseline. The vertical bars represent the means ± S.E.M. The P values were obtained from independent t-test. HCEt: hyul-bu-chuke-tang; h: hour. #P < 0.05 compared to the control group.

Mentions: The index of erythrocyte deformability (EI) at 1, 2, and 3 h was significantly greater than baseline in the HCEt group (Figure 1). The EI in the control group was not altered. HCEt administration significantly improved erythrocyte deformability after 1 hour compared to the control group (2.9 ± 1.1% (S.E.M) in 14 subjects versus −0.6 ± 1.0% in 10 subjects: 95% confidence interval for difference = 0.3–6.8%, P = 0.034). No difference in age between the two groups was observed.


Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO(2) Reactivity in Normal Subjects.

Jung WS, Park JY, Byeon HS, Kim YJ, Park JM, Park SU, Cho SY, Moon SK - Evid Based Complement Alternat Med (2012)

Change of erythrocyte deformability in the HCEt group (n = 14) and the control group (n = 10) at each time point. All values are the percent change compared to baseline. The vertical bars represent the means ± S.E.M. The P values were obtained from independent t-test. HCEt: hyul-bu-chuke-tang; h: hour. #P < 0.05 compared to the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368491&req=5

fig1: Change of erythrocyte deformability in the HCEt group (n = 14) and the control group (n = 10) at each time point. All values are the percent change compared to baseline. The vertical bars represent the means ± S.E.M. The P values were obtained from independent t-test. HCEt: hyul-bu-chuke-tang; h: hour. #P < 0.05 compared to the control group.
Mentions: The index of erythrocyte deformability (EI) at 1, 2, and 3 h was significantly greater than baseline in the HCEt group (Figure 1). The EI in the control group was not altered. HCEt administration significantly improved erythrocyte deformability after 1 hour compared to the control group (2.9 ± 1.1% (S.E.M) in 14 subjects versus −0.6 ± 1.0% in 10 subjects: 95% confidence interval for difference = 0.3–6.8%, P = 0.034). No difference in age between the two groups was observed.

Bottom Line: HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus -8.1 ± 4.1%, P = 0.007).The mean blood pressure and pulse rate did not vary from baseline values in either group.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea.

ABSTRACT
Aim. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO(2) reactivity (CVR) in healthy male subjects. Materials and Methods. We examined erythrocyte deformability in an HCEt group (n = 14) and a control group (n = 10). CVR was measured using hyperventilation-induced CO(2) reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group (n = 11). A historical control group (n = 10) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (2.9 ± 1.1% versus -0.6 ± 1.0%, P = 0.034). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus -8.1 ± 4.1%, P = 0.007). The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt's effect on cerebral microcirculation.

No MeSH data available.


Related in: MedlinePlus