Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.
Bottom Line: Fibroblast growth factor (FGF) signalling has important roles in the development of the embryonic pharyngeal (branchial) arches, but its effects on innervation of the arches and associated structures have not been studied extensively.However, epithelial-specific gene deletion only results in defects in the facial nerve and not the glossopharyngeal and vagus nerves, suggesting that the facial nerve is most sensitive to perturbations in RTK signalling.Reducing the Fgf8 gene dosage only partially rescued defects in the glossopharyngeal nerve and was not sufficient to rescue facial nerve defects, suggesting that FGF8 is functionally redundant with other RTK ligands during facial nerve development.
Affiliation: Department of Craniofacial Development, King's College London, Floor 27, Guy's Tower, London, SE1 9RT, UK.Show MeSH
Related in: MedlinePlus
Mentions: To determine whether Sprouty genes may have a function in the development of the epibranchial ganglia in the mouse, we analysed the expression of Spry1 and Spry2 between embryonic day (E)8.5 and E9.5 of development. At E8.5, Spry1 and Spry2 are both expressed in the pharyngeal ectoderm, endoderm and mesoderm (Figs. 1A–B′). This pattern of expression is consistent with the expression of several Fgf genes in these tissues at this time of development and the role of FGF signalling in the induction of otic fate (Ladher et al., 2010).
Affiliation: Department of Craniofacial Development, King's College London, Floor 27, Guy's Tower, London, SE1 9RT, UK.