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Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis.

Sun S, Dai J, Wang W, Cao H, Fang J, Hu YY, Su S, Zhang Y - Evid Based Complement Alternat Med (2012)

Bottom Line: Urine samples of 12 healthy volunteers (control group, CG) and 31 HBC patients (HBCG) were analyzed by gas chromatography mass spectrometry (GC/MS) and multivariate statistical analysis.The significantly changed metabolites between CG and HBCG were selected by PLS-DA loading plot analysis.The efficiency of FZHY tablet on subjects with spleen deficiency with dampness encumbrance syndrome (SDDES) and liver-kidney yin deficiency syndrome (LKYDS) was better than that of other syndromes.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China.

ABSTRACT
In Traditional Chinese Medicine (TCM), treatment based on ZHENG (also called TCM syndrome and pattern) differentiation has been applied for about 3 thousand years, while there are some difficulties to communicate with western medicine. In the present work, metabonomic methods were utilized to differentiate ZHENG types and evaluate the therapeutic efficiency of Fuzhenghuayu (FZHY) tablet in hepatitis-B-caused cirrhosis (HBC). Urine samples of 12 healthy volunteers (control group, CG) and 31 HBC patients (HBCG) were analyzed by gas chromatography mass spectrometry (GC/MS) and multivariate statistical analysis. The significantly changed metabolites between CG and HBCG were selected by PLS-DA loading plot analysis. Moreover, 4 ZHENGs were differentiated mutually, suggesting that there was urine metabolic material basis in ZHENG differentiation. The efficiency of FZHY tablet on subjects with spleen deficiency with dampness encumbrance syndrome (SDDES) and liver-kidney yin deficiency syndrome (LKYDS) was better than that of other syndromes. The efficiency of FZHY treatment based on ZHENG differentiation indicated that accurately ZHENG differentiating could guide the appropriate TCM treatment in HBC.

No MeSH data available.


Related in: MedlinePlus

HBC-related pathway observed in this research.
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Related In: Results  -  Collection


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fig2: HBC-related pathway observed in this research.

Mentions: Alanine and tyrosine, which are the substrates of alanine transaminase (ALT) and aspartate aminotransferase (AST), respectively, were upregulated in HBCG. And ALT and AST will increase when activated CD4+ and CD8+ lymphocytes recognize various HBV-derived proteins located on the surface of infected hepatocytes [19] (summarized in Figure 2). So the increase of alanine and tyrosine might suggest that HBC was correlated with the disorder of immune system, which was in agreement with the previous report that chronic HBV infection develops in the setting of impaired immune reactions or a relatively tolerant immune system status [20].


Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis.

Sun S, Dai J, Wang W, Cao H, Fang J, Hu YY, Su S, Zhang Y - Evid Based Complement Alternat Med (2012)

HBC-related pathway observed in this research.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368351&req=5

fig2: HBC-related pathway observed in this research.
Mentions: Alanine and tyrosine, which are the substrates of alanine transaminase (ALT) and aspartate aminotransferase (AST), respectively, were upregulated in HBCG. And ALT and AST will increase when activated CD4+ and CD8+ lymphocytes recognize various HBV-derived proteins located on the surface of infected hepatocytes [19] (summarized in Figure 2). So the increase of alanine and tyrosine might suggest that HBC was correlated with the disorder of immune system, which was in agreement with the previous report that chronic HBV infection develops in the setting of impaired immune reactions or a relatively tolerant immune system status [20].

Bottom Line: Urine samples of 12 healthy volunteers (control group, CG) and 31 HBC patients (HBCG) were analyzed by gas chromatography mass spectrometry (GC/MS) and multivariate statistical analysis.The significantly changed metabolites between CG and HBCG were selected by PLS-DA loading plot analysis.The efficiency of FZHY tablet on subjects with spleen deficiency with dampness encumbrance syndrome (SDDES) and liver-kidney yin deficiency syndrome (LKYDS) was better than that of other syndromes.

View Article: PubMed Central - PubMed

Affiliation: Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China.

ABSTRACT
In Traditional Chinese Medicine (TCM), treatment based on ZHENG (also called TCM syndrome and pattern) differentiation has been applied for about 3 thousand years, while there are some difficulties to communicate with western medicine. In the present work, metabonomic methods were utilized to differentiate ZHENG types and evaluate the therapeutic efficiency of Fuzhenghuayu (FZHY) tablet in hepatitis-B-caused cirrhosis (HBC). Urine samples of 12 healthy volunteers (control group, CG) and 31 HBC patients (HBCG) were analyzed by gas chromatography mass spectrometry (GC/MS) and multivariate statistical analysis. The significantly changed metabolites between CG and HBCG were selected by PLS-DA loading plot analysis. Moreover, 4 ZHENGs were differentiated mutually, suggesting that there was urine metabolic material basis in ZHENG differentiation. The efficiency of FZHY tablet on subjects with spleen deficiency with dampness encumbrance syndrome (SDDES) and liver-kidney yin deficiency syndrome (LKYDS) was better than that of other syndromes. The efficiency of FZHY treatment based on ZHENG differentiation indicated that accurately ZHENG differentiating could guide the appropriate TCM treatment in HBC.

No MeSH data available.


Related in: MedlinePlus