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Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine.

Chen Z, Chen LY, Wang P, Dai HY, Gao S, Wang K - Evid Based Complement Alternat Med (2012)

Bottom Line: In traditional Chinese medicine (TCM), diagnosis of pathology and choice of treatment prescriptions are based on a method of differentiation of signs and symptoms known as syndrome differentiation or ZHENG.We found that tumors of the different ZHENG models exhibited significantly altered cancer-associated fibroblast (CAF) proliferative activity and tumor-associated macrophage (TAM) infiltration, which led to altered levels of CAF- and TAM-derived secreted cytokines such as SDF-1 and CCL5.The ZHENG model type also significantly influenced tumor growth, and administration of herbal medicine to the ZHENG model modified the tumor microenvironment.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

ABSTRACT
In traditional Chinese medicine (TCM), diagnosis of pathology and choice of treatment prescriptions are based on a method of differentiation of signs and symptoms known as syndrome differentiation or ZHENG. The cornerstone of TCM, ZHENG, relies on the gathering of clinical information through inspection, auscultation and olfaction, inquiry, and palpation. However, the biomolecular basis of the ZHENG remains unclear. In this study, we established mouse xenograft pancreatic cancer models with Shi-Re (Dampness-Heat), Pi-Xu (Spleen-Deficiency), or Xue-Yu (Blood-Stasis) ZHENG, which are regarded as the three major ZHENGs in pancreatic cancer. We found that tumors of the different ZHENG models exhibited significantly altered cancer-associated fibroblast (CAF) proliferative activity and tumor-associated macrophage (TAM) infiltration, which led to altered levels of CAF- and TAM-derived secreted cytokines such as SDF-1 and CCL5. The ZHENG model type also significantly influenced tumor growth, and administration of herbal medicine to the ZHENG model modified the tumor microenvironment. Therefore, this study partially unveiled the molecular basis of TCM ZHENG in pancreatic cancer.

No MeSH data available.


Related in: MedlinePlus

Percentages of pancreatic patients diagnosed with various TCM ZHENG conditions. Data on ZHENG distribution were extracted and analyzed from 34 clinical articles published between January 1, 1998 and December 31, 2008.
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fig1: Percentages of pancreatic patients diagnosed with various TCM ZHENG conditions. Data on ZHENG distribution were extracted and analyzed from 34 clinical articles published between January 1, 1998 and December 31, 2008.

Mentions: We firstly investigated the distribution of ZHENG conditions in populations of pancreatic cancer patients based on reports published from January 1, 1998 to December 31, 2008. Sixty-nine studies were identified by electronic and hand searches, among which 34 clinical articles were included for our study. Data on ZHENG distribution were extracted and analyzed. Twenty-seven ZHENGs were identified. The three ZHENGs in pancreatic cancer that were most reported were Dampness-Heat (in Chinese, Shi-Re; 33.9% of studies), Spleen-Deficiency (Pi-Xu; 29.10%), and Blood-Stasis (Xue-Yu; 19.8%; Figure 1).


Tumor Microenvironment Varies under Different TCM ZHENG Models and Correlates with Treatment Response to Herbal Medicine.

Chen Z, Chen LY, Wang P, Dai HY, Gao S, Wang K - Evid Based Complement Alternat Med (2012)

Percentages of pancreatic patients diagnosed with various TCM ZHENG conditions. Data on ZHENG distribution were extracted and analyzed from 34 clinical articles published between January 1, 1998 and December 31, 2008.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368347&req=5

fig1: Percentages of pancreatic patients diagnosed with various TCM ZHENG conditions. Data on ZHENG distribution were extracted and analyzed from 34 clinical articles published between January 1, 1998 and December 31, 2008.
Mentions: We firstly investigated the distribution of ZHENG conditions in populations of pancreatic cancer patients based on reports published from January 1, 1998 to December 31, 2008. Sixty-nine studies were identified by electronic and hand searches, among which 34 clinical articles were included for our study. Data on ZHENG distribution were extracted and analyzed. Twenty-seven ZHENGs were identified. The three ZHENGs in pancreatic cancer that were most reported were Dampness-Heat (in Chinese, Shi-Re; 33.9% of studies), Spleen-Deficiency (Pi-Xu; 29.10%), and Blood-Stasis (Xue-Yu; 19.8%; Figure 1).

Bottom Line: In traditional Chinese medicine (TCM), diagnosis of pathology and choice of treatment prescriptions are based on a method of differentiation of signs and symptoms known as syndrome differentiation or ZHENG.We found that tumors of the different ZHENG models exhibited significantly altered cancer-associated fibroblast (CAF) proliferative activity and tumor-associated macrophage (TAM) infiltration, which led to altered levels of CAF- and TAM-derived secreted cytokines such as SDF-1 and CCL5.The ZHENG model type also significantly influenced tumor growth, and administration of herbal medicine to the ZHENG model modified the tumor microenvironment.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

ABSTRACT
In traditional Chinese medicine (TCM), diagnosis of pathology and choice of treatment prescriptions are based on a method of differentiation of signs and symptoms known as syndrome differentiation or ZHENG. The cornerstone of TCM, ZHENG, relies on the gathering of clinical information through inspection, auscultation and olfaction, inquiry, and palpation. However, the biomolecular basis of the ZHENG remains unclear. In this study, we established mouse xenograft pancreatic cancer models with Shi-Re (Dampness-Heat), Pi-Xu (Spleen-Deficiency), or Xue-Yu (Blood-Stasis) ZHENG, which are regarded as the three major ZHENGs in pancreatic cancer. We found that tumors of the different ZHENG models exhibited significantly altered cancer-associated fibroblast (CAF) proliferative activity and tumor-associated macrophage (TAM) infiltration, which led to altered levels of CAF- and TAM-derived secreted cytokines such as SDF-1 and CCL5. The ZHENG model type also significantly influenced tumor growth, and administration of herbal medicine to the ZHENG model modified the tumor microenvironment. Therefore, this study partially unveiled the molecular basis of TCM ZHENG in pancreatic cancer.

No MeSH data available.


Related in: MedlinePlus