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Evaluation of Hepatoprotective Effect of Leaves of Cassia sophera Linn.

Mondal A, Karan SK, Singha T, Rajalingam D, Maity TK - Evid Based Complement Alternat Med (2012)

Bottom Line: The substantially elevated serum enzymatic levels of AST, ALT, ALP, and total bilirubin were restored towards the normalization significantly by the extracts.The decreased serum total protein level was significantly normalized.Silymarin was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, West Bengal, Kolkata 700 032, India.

ABSTRACT
In the present study, the hepatoprotective activity of ethanolic extracts of Cassia sophera Linn. leaves was evaluated against carbon-tetrachloride- (CCl(4)-) induced hepatic damage in rats. The extracts at doses of 200 and 400 mg/kg were administered orally once daily. The hepatoprotection was assessed in terms of reduction in histological damage, changes in serum enzymes, serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP), total bilirubin, and total protein levels. The substantially elevated serum enzymatic levels of AST, ALT, ALP, and total bilirubin were restored towards the normalization significantly by the extracts. The decreased serum total protein level was significantly normalized. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that Cassia sophera leaves have potent hepatoprotective action against carbon tetrachloride-induced hepatic damage in rats. This study suggests that possible activity may be due to the presence of flavonoids in the extracts.

No MeSH data available.


Related in: MedlinePlus

Structure of Rhamnetin.
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Related In: Results  -  Collection


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fig1: Structure of Rhamnetin.

Mentions: Preliminary phytochemical screening of the ethanol extract of C. sophera revealed the presence of steroids, alkaloids, tannins, saponins, and flavonoids. Different compositions of the mobile phase were tested and the desired resolution of rhamnetin with symmetrical and reproducible peak was achieved by using the mobile phase chloroform and ethyl acetate. The structure of the compound was characterized by UV, IR, MS, and 13C-NMR methods as rhamnetin (Figure 1). Structures and the IR, 13C-NMR, and MS data obtained independently in these studies are in close conformity with reported literature [10, 16].


Evaluation of Hepatoprotective Effect of Leaves of Cassia sophera Linn.

Mondal A, Karan SK, Singha T, Rajalingam D, Maity TK - Evid Based Complement Alternat Med (2012)

Structure of Rhamnetin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368335&req=5

fig1: Structure of Rhamnetin.
Mentions: Preliminary phytochemical screening of the ethanol extract of C. sophera revealed the presence of steroids, alkaloids, tannins, saponins, and flavonoids. Different compositions of the mobile phase were tested and the desired resolution of rhamnetin with symmetrical and reproducible peak was achieved by using the mobile phase chloroform and ethyl acetate. The structure of the compound was characterized by UV, IR, MS, and 13C-NMR methods as rhamnetin (Figure 1). Structures and the IR, 13C-NMR, and MS data obtained independently in these studies are in close conformity with reported literature [10, 16].

Bottom Line: The substantially elevated serum enzymatic levels of AST, ALT, ALP, and total bilirubin were restored towards the normalization significantly by the extracts.The decreased serum total protein level was significantly normalized.Silymarin was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, West Bengal, Kolkata 700 032, India.

ABSTRACT
In the present study, the hepatoprotective activity of ethanolic extracts of Cassia sophera Linn. leaves was evaluated against carbon-tetrachloride- (CCl(4)-) induced hepatic damage in rats. The extracts at doses of 200 and 400 mg/kg were administered orally once daily. The hepatoprotection was assessed in terms of reduction in histological damage, changes in serum enzymes, serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (ALP), total bilirubin, and total protein levels. The substantially elevated serum enzymatic levels of AST, ALT, ALP, and total bilirubin were restored towards the normalization significantly by the extracts. The decreased serum total protein level was significantly normalized. Silymarin was used as standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that Cassia sophera leaves have potent hepatoprotective action against carbon tetrachloride-induced hepatic damage in rats. This study suggests that possible activity may be due to the presence of flavonoids in the extracts.

No MeSH data available.


Related in: MedlinePlus