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Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

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Related in: MedlinePlus

Lateral and axial resolution plots for imaging through samples of 1 and 11 μm beads of various concentrations, given by mean free path (mfp). Resolution was defined as the 10 to 90% rise in each dimension. Error bars are computed from the standard deviation of the background signal immediately adjacent to the reflector surface. Lateral resolution is relatively insensitive to number of scattering events, while axial resolution degrades continuously with increasing scattering.
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g006: Lateral and axial resolution plots for imaging through samples of 1 and 11 μm beads of various concentrations, given by mean free path (mfp). Resolution was defined as the 10 to 90% rise in each dimension. Error bars are computed from the standard deviation of the background signal immediately adjacent to the reflector surface. Lateral resolution is relatively insensitive to number of scattering events, while axial resolution degrades continuously with increasing scattering.

Mentions: Figure 6Fig. 6


Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Lateral and axial resolution plots for imaging through samples of 1 and 11 μm beads of various concentrations, given by mean free path (mfp). Resolution was defined as the 10 to 90% rise in each dimension. Error bars are computed from the standard deviation of the background signal immediately adjacent to the reflector surface. Lateral resolution is relatively insensitive to number of scattering events, while axial resolution degrades continuously with increasing scattering.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368313&req=5

g006: Lateral and axial resolution plots for imaging through samples of 1 and 11 μm beads of various concentrations, given by mean free path (mfp). Resolution was defined as the 10 to 90% rise in each dimension. Error bars are computed from the standard deviation of the background signal immediately adjacent to the reflector surface. Lateral resolution is relatively insensitive to number of scattering events, while axial resolution degrades continuously with increasing scattering.
Mentions: Figure 6Fig. 6

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

Show MeSH
Related in: MedlinePlus