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Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

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Related in: MedlinePlus

Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 11 μm microsphere scattering media for increasing concentrations, corresponding to 50 mfp, 62 mfp, 83 mfp and 94 mfp. With increasing scattering the reflector signal broadens out in both time and lateral position, resulting in progressively decreased resolution. However, even at 94 mfp photons that have interacted with the reflector remain distinct from the diffuse background signal.
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g004: Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 11 μm microsphere scattering media for increasing concentrations, corresponding to 50 mfp, 62 mfp, 83 mfp and 94 mfp. With increasing scattering the reflector signal broadens out in both time and lateral position, resulting in progressively decreased resolution. However, even at 94 mfp photons that have interacted with the reflector remain distinct from the diffuse background signal.

Mentions: The knife-edge experiments were repeated using 11 μm bead solutions to explore forward scattering in highly anisotropic media (Fig. 4Fig. 4


Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 11 μm microsphere scattering media for increasing concentrations, corresponding to 50 mfp, 62 mfp, 83 mfp and 94 mfp. With increasing scattering the reflector signal broadens out in both time and lateral position, resulting in progressively decreased resolution. However, even at 94 mfp photons that have interacted with the reflector remain distinct from the diffuse background signal.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368313&req=5

g004: Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 11 μm microsphere scattering media for increasing concentrations, corresponding to 50 mfp, 62 mfp, 83 mfp and 94 mfp. With increasing scattering the reflector signal broadens out in both time and lateral position, resulting in progressively decreased resolution. However, even at 94 mfp photons that have interacted with the reflector remain distinct from the diffuse background signal.
Mentions: The knife-edge experiments were repeated using 11 μm bead solutions to explore forward scattering in highly anisotropic media (Fig. 4Fig. 4

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

Show MeSH
Related in: MedlinePlus