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Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

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Related in: MedlinePlus

Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 1 μm microsphere scattering media for increasing concentrations, corresponding to 20, 25, 30, 35, and 40 mfp. Contrast gradually decreases until at 40 mfp the object is obscured. The 20 and 30 mfp scans have axial and lateral profiles shown through the center of the reflector, highlighting the axial and lateral extent of the diffusely scattered signal. Note that the 20 mfp image has both ballistic and diffuse peaks.
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g002: Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 1 μm microsphere scattering media for increasing concentrations, corresponding to 20, 25, 30, 35, and 40 mfp. Contrast gradually decreases until at 40 mfp the object is obscured. The 20 and 30 mfp scans have axial and lateral profiles shown through the center of the reflector, highlighting the axial and lateral extent of the diffusely scattered signal. Note that the 20 mfp image has both ballistic and diffuse peaks.

Mentions: Samples of 1 μm bead solution were prepared with increasing concentration and tomographically imaged with illumination and collection optics fixed at 6 degrees above and below the normal incidence respectively. Concentrations were chosen to begin with 20 mfp for the 1 cm path length the target, close to the ballistic limit, and then extend towards increasing scattering until imaging was no longer possible [Fig. 2Fig. 2


Imaging beyond the ballistic limit in coherence imaging using multiply scattered light.

Giacomelli MG, Wax A - Opt Express (2011)

Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 1 μm microsphere scattering media for increasing concentrations, corresponding to 20, 25, 30, 35, and 40 mfp. Contrast gradually decreases until at 40 mfp the object is obscured. The 20 and 30 mfp scans have axial and lateral profiles shown through the center of the reflector, highlighting the axial and lateral extent of the diffusely scattered signal. Note that the 20 mfp image has both ballistic and diffuse peaks.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368313&req=5

g002: Tomographic images of a 3.3 mm wide test reflector located 10 mm beneath the surface of 1 μm microsphere scattering media for increasing concentrations, corresponding to 20, 25, 30, 35, and 40 mfp. Contrast gradually decreases until at 40 mfp the object is obscured. The 20 and 30 mfp scans have axial and lateral profiles shown through the center of the reflector, highlighting the axial and lateral extent of the diffusely scattered signal. Note that the 20 mfp image has both ballistic and diffuse peaks.
Mentions: Samples of 1 μm bead solution were prepared with increasing concentration and tomographically imaged with illumination and collection optics fixed at 6 degrees above and below the normal incidence respectively. Concentrations were chosen to begin with 20 mfp for the 1 cm path length the target, close to the ballistic limit, and then extend towards increasing scattering until imaging was no longer possible [Fig. 2Fig. 2

Bottom Line: We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media.By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light.The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering and Fitzpatrick Center for Photonics, Duke University, Durham, NC 27708, USA.

ABSTRACT
We present an imaging system based on low coherence interferometric detection of multiply scattered light for extended depth imaging into highly scattering media. By incorporating angle-resolved detection, coherence imaging with multiply scattered photons is shown to be both feasible and potentially superior to existing techniques for performing time-resolved measurements of scattered light. Imaging is demonstrated through nearly 100 mean free paths of scattering phantom in a single-ended geometry. The resolution and imaging contrast are compared to those obtained with conventional OCT systems which chiefly detect singly scattered light.

Show MeSH
Related in: MedlinePlus