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Embryonal sarcoma of the liver in an adult patient.

Lightfoot N, Nikfarjam M - Case Rep Surg (2012)

Bottom Line: A case of an UES of the liver with an isolated peritoneal metastasis is described.The patient presented with a palpable mass with imaging findings suggestive of a cystic tumour.An UES should be considered in the differential of large cystic hepatic lesions, with aggressive surgical resection considered when possible.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, The University of Melbourne, Austin Health, Heidelberg, Melbourne, VIC 3084, Australia.

ABSTRACT
Undifferentiated embryonal sarcomas (UESs) are uncommon tumours that are seen predominantly in late childhood. Cases in adults are rare and generally present once a large mass develops and may be mistaken for other tumours. A case of an UES of the liver with an isolated peritoneal metastasis is described. The patient presented with a palpable mass with imaging findings suggestive of a cystic tumour. She had complete surgical resection of the liver mass and isolated peritoneal metastasis. She was tumour-free on imaging at 6 months without adjuvant chemotherapy. An UES should be considered in the differential of large cystic hepatic lesions, with aggressive surgical resection considered when possible.

No MeSH data available.


Related in: MedlinePlus

(a) Alpha1-antitrypsin immunohistochemistry diffusely staining tumour cells (×200). (b) Vimentin immunohistochemistry staining tumour cells (×200). (c) PAS-positive, diastase-resistant intratumoral cytoplasmic and extracellular eosinophilic globules (×200). (d) Malignant hepatoid tumour nodule within the tumour (hematoxylin and eosin, ×200).
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fig3: (a) Alpha1-antitrypsin immunohistochemistry diffusely staining tumour cells (×200). (b) Vimentin immunohistochemistry staining tumour cells (×200). (c) PAS-positive, diastase-resistant intratumoral cytoplasmic and extracellular eosinophilic globules (×200). (d) Malignant hepatoid tumour nodule within the tumour (hematoxylin and eosin, ×200).

Mentions: Histology of the tumour revealed variable morphology. Prominent intratumoral necrosis was seen, and there was moderate mitotic activity. The morphological and immunohistochemical profile was consistent with undifferentiated embryonal sarcoma. The tumour was comprised of densely cellular areas of rounded and pleomorphic cells and myxoid more paucicellular areas with stellate and spindled cells (Figure 2). Tumour cells stained positively for AE1/AE3, alpha1-antitrypsin, vimentin, and desmin. Variably sized eosinophilic, intracytoplasmic, PAS-positive, diastase resistant globules were also noted within occasional tumour cells (Figure 3). In addition, nodules of malignant hepatoid tumour were admixed with the undifferentiated areas (Figure 3(d)) and stained positively for HepPar-1, polyclonal carcinomembryonic antigen, and AE1/AE3.


Embryonal sarcoma of the liver in an adult patient.

Lightfoot N, Nikfarjam M - Case Rep Surg (2012)

(a) Alpha1-antitrypsin immunohistochemistry diffusely staining tumour cells (×200). (b) Vimentin immunohistochemistry staining tumour cells (×200). (c) PAS-positive, diastase-resistant intratumoral cytoplasmic and extracellular eosinophilic globules (×200). (d) Malignant hepatoid tumour nodule within the tumour (hematoxylin and eosin, ×200).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3368299&req=5

fig3: (a) Alpha1-antitrypsin immunohistochemistry diffusely staining tumour cells (×200). (b) Vimentin immunohistochemistry staining tumour cells (×200). (c) PAS-positive, diastase-resistant intratumoral cytoplasmic and extracellular eosinophilic globules (×200). (d) Malignant hepatoid tumour nodule within the tumour (hematoxylin and eosin, ×200).
Mentions: Histology of the tumour revealed variable morphology. Prominent intratumoral necrosis was seen, and there was moderate mitotic activity. The morphological and immunohistochemical profile was consistent with undifferentiated embryonal sarcoma. The tumour was comprised of densely cellular areas of rounded and pleomorphic cells and myxoid more paucicellular areas with stellate and spindled cells (Figure 2). Tumour cells stained positively for AE1/AE3, alpha1-antitrypsin, vimentin, and desmin. Variably sized eosinophilic, intracytoplasmic, PAS-positive, diastase resistant globules were also noted within occasional tumour cells (Figure 3). In addition, nodules of malignant hepatoid tumour were admixed with the undifferentiated areas (Figure 3(d)) and stained positively for HepPar-1, polyclonal carcinomembryonic antigen, and AE1/AE3.

Bottom Line: A case of an UES of the liver with an isolated peritoneal metastasis is described.The patient presented with a palpable mass with imaging findings suggestive of a cystic tumour.An UES should be considered in the differential of large cystic hepatic lesions, with aggressive surgical resection considered when possible.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, The University of Melbourne, Austin Health, Heidelberg, Melbourne, VIC 3084, Australia.

ABSTRACT
Undifferentiated embryonal sarcomas (UESs) are uncommon tumours that are seen predominantly in late childhood. Cases in adults are rare and generally present once a large mass develops and may be mistaken for other tumours. A case of an UES of the liver with an isolated peritoneal metastasis is described. The patient presented with a palpable mass with imaging findings suggestive of a cystic tumour. She had complete surgical resection of the liver mass and isolated peritoneal metastasis. She was tumour-free on imaging at 6 months without adjuvant chemotherapy. An UES should be considered in the differential of large cystic hepatic lesions, with aggressive surgical resection considered when possible.

No MeSH data available.


Related in: MedlinePlus