The host-seeking inhibitory peptide, Aea-HP-1, is made in the male accessory gland and transferred to the female during copulation.
Bottom Line: The structure of the peptide with its blocked N- and C-termini confers resistance to metabolic inactivation by MAG peptidases; however the peptide persists for less than 2h in the female reproductive tract after copulation.Aea-HP-1 is not a ligand for the mosquito sex peptide/myoinhibitory peptide receptor.A. aegypti often mate close to the host and therefore it is possible that male-derived Aea-HP-1 induces short-term changes to female host-seeking behavior to reduce potentially lethal encounters with hosts soon after insemination.
Affiliation: Faculty of Biological Sciences, University of Leeds, Leeds, UK. email@example.comShow MeSH
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Mentions: Reproductive tissues of A. aegypti are known to be rich in peptidases that might be involved in the metabolism of MAG peptides . We confirmed the presence of peptide-degrading peptidases using the insect peptide, APSGFLGVRamide, as a substrate. Under conditions that resulted in over 96% hydrolysis of APSGFLGVRamide, only 8% of Aea-HP-1 was degraded, demonstrating the relative stability of Aea-HP-1 to MAG enzymes (Fig. 5).
Affiliation: Faculty of Biological Sciences, University of Leeds, Leeds, UK. firstname.lastname@example.org