Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.
Bottom Line: However, whether lowering 5-HT alters the dynamic interplay between the PFC and the amygdala has not been directly tested in humans.Data from 19 subjects were available for the final analyses.We provide strong support for neurobiological accounts positing that 5-HT significantly influences PFC-amygdala circuits implicated in aggression and other affective behaviors.
Affiliation: Unità di Ricerca Neuroimmagini, Consiglio Nazionale delle Ricerche, Catanzaro, Italy. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: For placebo, RFX-BMS indicated evidence favoring model C1.1 (Figure 3B–E). In this family (Figure 3A), driving inputs (all faces) entered the system via the amygdala alone, whereas the angry vs. neutral modulator affected bidirectional connections in all three pathways. Hence, during placebo, the effect of the task is distributed within internal PFC circuitry and across PFC–amygdala connections.
Affiliation: Unità di Ricerca Neuroimmagini, Consiglio Nazionale delle Ricerche, Catanzaro, Italy. firstname.lastname@example.org