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Sinonasal malignancies and charged particle radiation treatment: a systematic literature review.

Cianchetti M, Amichetti M - Int J Otolaryngol (2012)

Bottom Line: We found six studies with data on clinical outcome.Conclusion.Promising results achieved so far must be confirmed in further studies.

View Article: PubMed Central - PubMed

Affiliation: Agenzia Provinciale per la Protonterapia Trento (ATrep), Via Fratelli Perini, 181, 38122 Trento, Italy.

ABSTRACT
Background. Paranasal and nasal cavity malignancies are rare tumors that frequently present at advanced stages. Tumor extension and anatomic complexity pose a challenge for their treatment. Due to their peculiar physical and biological properties particle radiation therapy, i.e. protons and ions can have a role in their management. We performed a systematic literature review to gather clinical evidence about their use to treat sinonasal malignancies. Materials and Methods. We searched the browsers PubMed and Medline as well as specific journals and conference proceedings. Inclusion criteria were: at least 10 patients, English language, reporting outcome and/or toxicity data. Results. We found six studies with data on clinical outcome. Carbon and helium ions were each used in one study, protons in four. Toxicity was specifically described in five studies. One reported acute toxicity of carbon ions, one dealt with brain toxicity from both carbon ions and protons. Three papers reported on visual toxicity: one from carbon ions, one from protons and one from both. Specific data were extracted and compared with the most pertinent literature. Conclusion. Particle radiation therapy is in its early phase of development. Promising results achieved so far must be confirmed in further studies.

No MeSH data available.


Related in: MedlinePlus

Flowchart of the searching process.
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fig2: Flowchart of the searching process.

Mentions: The initial literature research identified 2012 studies including duplicates (see Figure 2). 1985 were excluded after reading the title or the abstract, as they did not fulfill the inclusion criteria. Twenty-seven studies remained and were considered for inclusion. After thorough reading of the full text, two studies were excluded as specific data of sinonasal malignancies were not available and fourteen were also excluded as they have subsequently been updated or because their data had already been included in other papers with larger numbers. At the end of the searching process, we identified six studies reporting outcome data (see Tables 1, 2, 3) of which two dealt with ions and four with protons. Five studies reporting exclusively toxicity were also included, two on ions, one on protons, and two on both (see Tables 4, 5).


Sinonasal malignancies and charged particle radiation treatment: a systematic literature review.

Cianchetti M, Amichetti M - Int J Otolaryngol (2012)

Flowchart of the searching process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368195&req=5

fig2: Flowchart of the searching process.
Mentions: The initial literature research identified 2012 studies including duplicates (see Figure 2). 1985 were excluded after reading the title or the abstract, as they did not fulfill the inclusion criteria. Twenty-seven studies remained and were considered for inclusion. After thorough reading of the full text, two studies were excluded as specific data of sinonasal malignancies were not available and fourteen were also excluded as they have subsequently been updated or because their data had already been included in other papers with larger numbers. At the end of the searching process, we identified six studies reporting outcome data (see Tables 1, 2, 3) of which two dealt with ions and four with protons. Five studies reporting exclusively toxicity were also included, two on ions, one on protons, and two on both (see Tables 4, 5).

Bottom Line: We found six studies with data on clinical outcome.Conclusion.Promising results achieved so far must be confirmed in further studies.

View Article: PubMed Central - PubMed

Affiliation: Agenzia Provinciale per la Protonterapia Trento (ATrep), Via Fratelli Perini, 181, 38122 Trento, Italy.

ABSTRACT
Background. Paranasal and nasal cavity malignancies are rare tumors that frequently present at advanced stages. Tumor extension and anatomic complexity pose a challenge for their treatment. Due to their peculiar physical and biological properties particle radiation therapy, i.e. protons and ions can have a role in their management. We performed a systematic literature review to gather clinical evidence about their use to treat sinonasal malignancies. Materials and Methods. We searched the browsers PubMed and Medline as well as specific journals and conference proceedings. Inclusion criteria were: at least 10 patients, English language, reporting outcome and/or toxicity data. Results. We found six studies with data on clinical outcome. Carbon and helium ions were each used in one study, protons in four. Toxicity was specifically described in five studies. One reported acute toxicity of carbon ions, one dealt with brain toxicity from both carbon ions and protons. Three papers reported on visual toxicity: one from carbon ions, one from protons and one from both. Specific data were extracted and compared with the most pertinent literature. Conclusion. Particle radiation therapy is in its early phase of development. Promising results achieved so far must be confirmed in further studies.

No MeSH data available.


Related in: MedlinePlus