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Preliminary results of hyperthermic intraperitoneal intraoperative chemotherapy as an adjuvant in resectable pancreatic cancer.

Tentes AA, Kyziridis D, Kakolyris S, Pallas N, Zorbas G, Korakianitis O, Mavroudis C, Courcoutsakis N, Prasopoulos P - Gastroenterol Res Pract (2012)

Bottom Line: Conclusions.Increased morbidity and mortality from intraoperative gemcitabine was not apparent.Further studies with greater number of patients are required to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Surgical Department, Didimotichon General Hospital, Didimotichon 68300, Greece.

ABSTRACT
Background and Aims. 5-year survival in patients with pancreatic cancer is poor. Surgical resection is the only potentially curative resection. The results of adjuvant treatment either with chemotherapy or with radiotherapy have been contradictory and the incidence of local-regional recurrence remains high. If local-regional recurrence is controlled survival may be expected to increase. Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) may be used in order to control local-regional recurrences. The purpose of the study is to identify the effect of HIPEC in patients with pancreatic cancer undergoing potentially resection. Patients and Methods. From 2007-2011, 21 patients, mean age 69.4 ± 9.5 (50-86) years, underwent tumor resection, and HIPEC with gemcitabine. The hospital mortality and morbidity rate was 9.5% and 33.3%, respectively. 5-year and median survival was 23% and 11 months, respectively. The recurrence rate was 50% but no patient developed local-regional recurrence. No patient was recorded with gemcitabine-induced toxicity. Conclusions. This clinical study of 21 patients is the first to combine an R(0) pancreas cancer resection with HIPEC. Increased morbidity and mortality from intraoperative gemcitabine was not apparent. Patients with pancreatic cancer undergoing potentially curative resection in combination with HIPEC may be offered a survival benefit. Data suggested that local-regional recurrences may be greatly reduced. Further studies with greater number of patients are required to confirm these findings.

No MeSH data available.


Related in: MedlinePlus

Overall survival of 21 patients with pancreatic cancer treated with complete resection plus hyperthermic intraoperative intraperitoneal chemotherapy.
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Related In: Results  -  Collection


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fig1: Overall survival of 21 patients with pancreatic cancer treated with complete resection plus hyperthermic intraoperative intraperitoneal chemotherapy.

Mentions: The 5-year survival rate was 23% and the median survival 11 months (Figure 1). Eleven stage III patients received systemic adjuvant chemotherapy with gemcitabine. One of the patients with stage II disease died during the immediate postoperative period. The median disease-free survival time was 5 months. The median follow-up time was 7 months. During followup 9 patients (50%) were recorded with recurrence. Three of them were stage II and 6 were stage III. All these patients had liver metastases and no locoregional recurrence, was recorded.


Preliminary results of hyperthermic intraperitoneal intraoperative chemotherapy as an adjuvant in resectable pancreatic cancer.

Tentes AA, Kyziridis D, Kakolyris S, Pallas N, Zorbas G, Korakianitis O, Mavroudis C, Courcoutsakis N, Prasopoulos P - Gastroenterol Res Pract (2012)

Overall survival of 21 patients with pancreatic cancer treated with complete resection plus hyperthermic intraoperative intraperitoneal chemotherapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3368190&req=5

fig1: Overall survival of 21 patients with pancreatic cancer treated with complete resection plus hyperthermic intraoperative intraperitoneal chemotherapy.
Mentions: The 5-year survival rate was 23% and the median survival 11 months (Figure 1). Eleven stage III patients received systemic adjuvant chemotherapy with gemcitabine. One of the patients with stage II disease died during the immediate postoperative period. The median disease-free survival time was 5 months. The median follow-up time was 7 months. During followup 9 patients (50%) were recorded with recurrence. Three of them were stage II and 6 were stage III. All these patients had liver metastases and no locoregional recurrence, was recorded.

Bottom Line: Conclusions.Increased morbidity and mortality from intraoperative gemcitabine was not apparent.Further studies with greater number of patients are required to confirm these findings.

View Article: PubMed Central - PubMed

Affiliation: Surgical Department, Didimotichon General Hospital, Didimotichon 68300, Greece.

ABSTRACT
Background and Aims. 5-year survival in patients with pancreatic cancer is poor. Surgical resection is the only potentially curative resection. The results of adjuvant treatment either with chemotherapy or with radiotherapy have been contradictory and the incidence of local-regional recurrence remains high. If local-regional recurrence is controlled survival may be expected to increase. Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) may be used in order to control local-regional recurrences. The purpose of the study is to identify the effect of HIPEC in patients with pancreatic cancer undergoing potentially resection. Patients and Methods. From 2007-2011, 21 patients, mean age 69.4 ± 9.5 (50-86) years, underwent tumor resection, and HIPEC with gemcitabine. The hospital mortality and morbidity rate was 9.5% and 33.3%, respectively. 5-year and median survival was 23% and 11 months, respectively. The recurrence rate was 50% but no patient developed local-regional recurrence. No patient was recorded with gemcitabine-induced toxicity. Conclusions. This clinical study of 21 patients is the first to combine an R(0) pancreas cancer resection with HIPEC. Increased morbidity and mortality from intraoperative gemcitabine was not apparent. Patients with pancreatic cancer undergoing potentially curative resection in combination with HIPEC may be offered a survival benefit. Data suggested that local-regional recurrences may be greatly reduced. Further studies with greater number of patients are required to confirm these findings.

No MeSH data available.


Related in: MedlinePlus